Results 21 to 30 of about 238 (143)

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Subacute combined degeneration from nitrous oxide abuse

Radiology Case Reports
Nitrous oxide is an anesthetic medication which can also be recreationally abused in the form of whippet canisters. Its prolonged abuse can interfere with Vitamin B12 metabolism and lead to its functional deficiency.
Harjinder Singh, MD, Nitya Beriwal, MD, Jasdeep Singh Minhas, BS, Ciji Robinson, MD   +3 more
doaj   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Subacute combined spinal cord degeneration and pancytopenia secondary to severe vitamin B12 deficiency

São Paulo Medical Journal
CONTEXT: Decreased vitamin B12 concentration does not usually result in clinical or hematological abnormalities. Subacute combined spinal cord degeneration and pancytopenia are two serious and rarely displayed consequences that appear in severe deficits.
José Luis Cabrerizo-García, Mariano Sebastián-Royo, Nerea Montes, Begoña Zalba-Etayo   +3 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Anchor‐Based Double‐Row Suture‐Bridge Repair for Stener‐Like Distal Medial Collateral Ligament Lesions of the Knee

Arthroscopy Techniques, EarlyView.
Abstract Stener‐like distal injuries of the superficial medial collateral ligament (MCL) are characterized by displacement of the distal ligament stump superficial to the pes anserinus fascia, preventing anatomic healing and resulting in persistent valgus and anteromedial rotatory instability.
Logan D. Moews, Napatpong Thamrongskulsiri, Jacob T. Morgan, Felipe Casanova, Cesar Alejandro Jiménez‐Aroche, Tanner Nishioka, Jorge Chahla   +6 more
wiley   +1 more source

Arthroscopic Primary Repair of Mid‐Substance Posterior Cruciate Ligament Tears With Knotless Dual‐Suspensory Fixation

Arthroscopy Techniques, EarlyView.
Abstract Posterior cruciate ligament (PCL) tears can spontaneously heal, but often heal with excess laxity. In contrast to well‐documented arthroscopic proximal and distal PCL tear repairs, the most prevalent mid‐substance tear is typically managed conservatively, or with full reconstruction.
Nancy Park, Soheil Sabzevari, Jonathan M. Salandra, Isabelle Shen, Jim C. Hsu   +4 more
wiley   +1 more source

Subacute combined degeneration of the spinal cord in functional vitamin B12 deficiency states

Advances in Clinical Neuroscience & Rehabilitation, 2021
Vitamin B12 is an essential enzymatic cofactor in multiple cellular metabolic pathways. Deficiency states can arise as a result of both depletion of absolute systemic levels and pathological processes that block its ability to act as an enzymatic ...
Christina Englezou, Di Liang
doaj   +1 more source