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The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

open access: yesFEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav   +4 more
wiley   +1 more source
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Subaltern Studies In A U.S. Frame

boundary 2, 1996
Theorizing colonial history for a postcolonial critical practice, Ranajit Guha observes, "Bourgeois culture hits its historical limit in colonialism. None of its noble achievements--Liberalism, Democracy, Liberty, Rule of Law, etc.-can survive the inexorable urge of capital to expand and reproduce itself by means of the politics of extra-territorial ...
openaire   +1 more source

The dis/appearance of subalterns: A reading of a decade of subaltern studies

South Asia: Journal of South Asian Studies, 1992
Ranajit Guha (ed.), Subaltern Studies. Writings on South Asian History and Society, Delhi, Oxford University Press, 1982, Vol. I, x, pp. 241 Rs.90; 1983, Vol. II, xii, pp. 358 Rs. 125; 1984, Vol. III, xii, pp. 327 Rs. 135; 1985, Vol. IV, xii, pp. 383 Rs. 160; 1987, Vol. V, x, pp. 296 Rs.150; 1989, Vol. VI, x, pp. 335 Rs.200.
openaire   +1 more source

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