Results 81 to 90 of about 13,073,871 (296)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Is there a subaltern political thought? A study on the Subaltern Studies: 1982-2000

, 2015
Essa pesquisa apresenta como objeto central os Subaltern Studies. Trata-se de um grupo de intelectuais que se destacou no estudo da história social e política indiana no final dos anos 1970.
Camila Massaro de Góes, Góes, Camila Massaro de   +1 more
core   +1 more source

Epistemologie del Sud: il postcolonialismo e lo studio delle relazioni internazionali [PDF]

Diacronie. Studi di Storia Contemporanea, 2014
The article discusses the emergence of postcolonial studies, situating the theoretical debates of the field of study of International Relations. It was from the second half of the twentieth century, with the processes of decolonization and globalization,
Antônio Manoel Elíbio Júnior, Carolina Soccio Di Manno de Almeida   +1 more
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Scheer, Catherine, 2022, "Subaltern soldiers: Overshawed Bunong highlanders in the Khmer Republic's army 1970-75"

, 2022
Scheer, Catherine, 2022, "Subaltern soldiers: Overshawed Bunong highlanders in the Khmer Republic's army 1970-75", Journal of Southeast Asian Studies https://www.cambridge.org/core/journals/journal-of-southeast-asian-studies/article/abs/subaltern ...
Sophie Hénon
core  

Reflection of the Concept of Spivak’s Subaltern in The Nine Parts of Desire by Heather Raffo and Mastaneh, the History of the Forgotten by Naghmeh Samini [PDF]

زن در فرهنگ و هنر
This investigation applies Spivak's "Subaltern Theory" to undertake a comparative examination of Mastaneh, the History of the Forgotten and Nine Parts of Desire.
Tuba Mozafari nezhad, Esmaeil Najar
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Aux marges de l’Histoire. Séminaire de recherche en dialogue avec les subaltern studies

, 2019
UCLouvain/LaRHis, Aux marges de l’Histoire. Séminaire de recherche en dialogue avec les subaltern studies, organisé par Silvia Mostaccio et Costantino Paonessa (Alessandra Marchi (Università di Cagliari-GramsciLab), Groupes subalternes/subalternité dans ...
Mostaccio, Silvia, Aux marges de l’Histoire. Séminaire de recherche en dialogue avec les subaltern studies   +1 more
core