Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]
, 2016 BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois +10 more
core +3 more sources
Neuroinflammation as a Target for Intervention in Subarachnoid Hemorrhage
Frontiers in Neurology, 2018 Aneurysmal subarachnoid hemorrhage (SAH) is a sub-type of hemorrhagic stroke associated with the highest rates of mortality and long-term neurological disabilities.
A. L. de Oliveira Manoel, R. Macdonald
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Brain Sciences, 2020 The Special Issue “Experimental and Clinical Treatment of Subarachnoid Hemorrhage after the Rupture of Saccular Intracranial Aneurysms” provides an excellent insight into the many facets of aneurysmal subarachnoid hemorrhage [...]
Serge Marbacher, John H. Zhang
doaj +1 more source
The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications [PDF]
, 2022 Rong Li +7 more
openalex +1 more source
Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities
Advanced Materials, EarlyView.As healthcare moves toward decentralization, ultrasound technologies are evolving from strictly imaging tools in clinical settings into versatile diagnostic and therapeutic platforms, with growing roles addressing women's health needs. This review highlights how ultrasound's underlying physical mechanisms can be harnessed to reduce disparities in women'
Sarah B. Ornellas +7 more
wiley +1 more source
Neural Regeneration Research, 2019 The Wnt/Frizzled signaling pathway participates in many inflammation-linked diseases. However, the inflammatory response mediated by the Wnt/Frizzled signaling pathway in experimental subarachnoid hemorrhage has not been thoroughly investigated ...
Yang Wang +6 more
doaj +1 more source
Subarachnoid Haemorrhage in Malta : Are outcomes adversely affected due to lack of a local neurovascular service? [PDF]
, 2014 Objective: This study was performed to assess the incidence, treatment and outcome of non-traumatic Subarachnoid Haemorrhage (SAH) in an island which does not offer a neurovascular service and to determine whether such limitation is associated with a ...
Aquilina, Josanne +4 more
core
Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial [PDF]
, 2007 <p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the ...
Ahlberg, G. +12 more
core +1 more source
Spinal Subarachnoid Hemorrhage Migrated from Traumatic Intracranial Subarachnoid Hemorrhage [PDF]
Korean Journal of Neurotrauma, 2016 Very rarely, spinal subarachnoid hemorrhage (SSAH) can occur without any direct spinal injury in patients with traumatic intracranial SAH. A-59-year-old male with traumatic intracranial subarachnoid hemorrhage (SAH) presented with pain and numbness in his buttock and thigh two days after trauma.
Kim, Tae Jin +2 more
openaire +2 more sources