Results 251 to 260 of about 796,231 (315)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Occult small bowel perforation presenting as extensive subcutaneous emphysema without skin breach. [PDF]

J Surg Case Rep
Barden A, Bhattacharya U, Pangeni A, Harinath G, Naik P.   +4 more
europepmc   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Sudden Respiratory Impairment due to Simultaneous Airway Obstruction and Tension Pneumothorax in a Patient Who Underwent Tracheostomy. [PDF]

Clin Case Rep
Ono Y, Shinohara K, Nakanishi N, Takayama K, Kondo Y.   +4 more
europepmc   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Molecular identification of Hypoderma sinense cutaneous myiasis in a child from a cattle-raising pastoral region of China: a case report. [PDF]

Trop Med Health
Ji Q, He S, Lai S, Long S, Jing X, Lu Y.
europepmc   +1 more source

Combination of PD-1 inhibitor and chemotherapy for subcutaneous soft-tissue metastasis in postoperative non-small cell lung cancer: A case report. [PDF]

Medicine (Baltimore)
Zeng Q, Yang B, Hu Y, Zeng Y.
europepmc   +1 more source

Subcutaneous methotrexate compared with oral methotrexate in rheumatoid arthritis: a systematic review and meta-analysis. [PDF]

Front Immunol
Li G, Xie W, Liu J, Geng Y, Zhang Z.
europepmc   +1 more source

Multimodal Assessment of Breast Cancer-Related Lymphedema Using Bioimpedance Analysis, Ultrasound Tissue Thickness, and Shear Wave Elastography. [PDF]

Diagnostics (Basel)
Bang MH, Song HL, Jo G, Do HK.
europepmc   +1 more source

Real-world experience with foslevodopa/foscarbidopa in Germany: therapeutic insights and lessons learned. [PDF]

Neurol Res Pract
Weise D, Warnecke T, Buhmann C, Ebersbach G, Eggers C, Falkenburger B, Höglinger G, Mollenhauer B, Pedrosa D, Südmeyer M, Weiss D, Kassubek J, Jost WH.   +12 more
europepmc   +1 more source