Results 291 to 300 of about 1,043,035 (341)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Extremity Ultrasound vs. Computed Tomography at the Third Lumbar Vertebra Level for Assessing the Subcutaneous Adipose Tissue-to-Muscle Ratio. [PDF]

Nutrients
Fischer-Hammerschmied A, Pesta M, Hertwig A, Siebenrock T, Hahn R, Anwar M, Liebau K, Timmermann I, Brugger J, Posch M, Ringl H, Tamandl D, Veraar C, Lassnigg A, Bernardi M, Tschernko E, Jonckheer J, Sundström Rehal M, Hiesmayr M.   +18 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Spontaneous Pneumomediastinum Following Intense Gym Exercise in a Healthy Young Male: A Case Report. [PDF]

Cureus
Elhag HM, Elmoheen A, Khyatt O, Shakeeb M, Al-Marri NDR.   +4 more
europepmc   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Management of Visual Loss Following Hyaluronic Acid Filler Injections: An Algorithm-based Approach. [PDF]

Plast Reconstr Surg Glob Open
Snozzi P, van Loghem JAJ, Nguyen H, Luft AR, Saeed P.   +4 more
europepmc   +1 more source

Subcutaneous dirofilariasis

Oxford Medical Case Reports
Poorvi Sharma, Nitin Gupta, Idzi Potters, Anjely Sebastian, Muralidhar Varma, Juhi Irfana Basheer, R Balakrishnan, Nancy Namrata Mahapatra, Vishwapriya M Godkhindi, Kanthilatha Pai, Anuradha Calicut Kini Rao   +10 more
openaire   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Advanced gastroesophageal junction adenocarcinoma with skin involvement: a multidisciplinary perspective. [PDF]

Oxf Med Case Reports
Alqasem K, Alshwayyat S, Aljawabrah S, Alfrajat L, Al-Atiyat R, Hajjaj R, BanyAmer A, Shattal MA, Al-Shatti M, Al-Kurdi MA.   +9 more
europepmc   +1 more source

A numerical study on the effect of laser therapy against port-wine stain by administering artificial red blood cells. [PDF]

Lasers Med Sci
Yoneoka S, Ogo T, Rikihisa N, Hyakutake T.   +3 more
europepmc   +1 more source