Results 141 to 150 of about 501,232 (307)

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

Advanced Science, EarlyView.
A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba, Miroslav Kuba, Tomáš Kraus, Kerem Celikay, Janis Meyer, Sunil Kumar Pradhan, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Karl Rohr, Michal Hocek, M. Cristina Cardoso   +11 more
wiley   +1 more source

Inclinometer use in primary total hip arthroplasty does not improve acetabular component positioning: a non-randomized control trial

Arthroplasty
Introduction Total hip arthroplasty (THA) is a common surgical procedure that aims to relieve pain, improve function, and increase mobility in patients with hip joint pathology. One of the most challenging aspects of THA is to determine the correct angle
Kyle Goldstein, Wyatt Tyndall, Michaela E. Nickol, Johannes M. van der Merwe   +3 more
doaj   +1 more source

Transport Matters: The Critical Role of the Hydrogen Evolution Reaction (HER) in Accelerating Electrochemical Nitrate to Ammonia Conversion

Advanced Science, EarlyView.
A porous cobalt‐based metal‐oxide foam catalyst is synthesized using the DHBT technique, followed by calcination. It demonstrates exceptional activity for e‐NO3RR, reaching near‐unity ammonia selectivity at low overpotentials. Dynamic surface area changes due to NO3‐ depletion are mitigated by “self‐convection” during hydrogen evolution.
Nandu Ashtaman‐Pillai Syamaladevi, Abhijit Dutta, Alain Rieder, Xin Yu, Hridya Nedumkulam, Jakub Drnec, Zsolt Szakály, Soma Vesztergom, Rebecca Katharina Pittkowski, Peter Broekmann   +9 more
wiley   +1 more source

Serological Subdivisions among the Lancefield Group H Streptococci

, 1954
E. D. Farmer
openalex   +1 more source

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source

An Apparent Dependence of the Radial Velocities and Proper Motions upon Magnitudes and Spectral Subdivisions of the Stars Within Class B

, 1915
C. D. Perrine
openalex   +1 more source

Subdivisions of digraphs

, 2014
Dans ce travail, nous considérons le problème suivant : étant donné un graphe orienté D, contient-il une subdivision d’un digraphe fixé F ? Nous pensons qu’il existe une dichotomie entre les instances polynomiales et NP-complètes. Nous donnons plusieurs exemples pour les deux cas. En particulier, sauf pour cinq instances, nous sommes capable de classer
openaire   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Genetical Effects of Population Subdivision [PDF]

, 1959

openalex   +1 more source