Results 171 to 180 of about 501,232 (307)

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

open access: yesAdvanced Science, EarlyView.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun   +13 more
wiley   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

open access: yesAdvanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam   +3 more
wiley   +1 more source

Gold Nanoturf‐Mediated Wireless Photothermal Upregulation of Human Adipose‐Derived Stem Cell Spheroids for Synergistic Skin‐Wound Closure

open access: yesAdvanced Science, EarlyView.
A wireless skin‐wound care platform for photothermal‐stem cell‐light (PTSCL) therapy, introduced here, leverages a fully wireless and battery‐free optoelectronic module, gold nanoturf‐mediated photothermal interface, and human adipose‐derived stem cell (hADSC) spheroids to synergistically enhance wound healing.
Jong Uk Kim   +17 more
wiley   +1 more source

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates. [PDF]

open access: yesSci Adv
Totty MS   +18 more
europepmc   +1 more source

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