Results 91 to 100 of about 696,277 (238)

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

open access: yesAdvanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin   +6 more
wiley   +1 more source

The M-polynomial of line graph of subdivision graphs

open access: yes, 2019
Three composite graphs Ladder graph (L_{n}), Tadpole graph (T_{n,k}) and Wheel graph (W_{n}) are graceful graphs, which have different applications in electrical, electronics, wireless communication etc. In this report, we first determine M-polynomial of
Mondal, Sourav, De, Nilanjan, Pal, Anita
core   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu   +5 more
wiley   +1 more source

Discrete Differential Form Subdivision and Vector Field Generation over Volumetric Domain [PDF]

open access: yes, 2012
This thesis presents a new method to construct smooth l- and 2-form subdivision schemes over the 3D volumetric domain. Based on the subdivided 1- and 2-form coefficient field, smooth vector fields can be constructed using Whitney forms.
Huang, Jinghao
core   +1 more source

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki   +10 more
wiley   +1 more source

Generalized Characteristic Polynomials of Join Graphs and Their Applications

open access: yesDiscrete Dynamics in Nature and Society, 2017
The Kirchhoff index of G is the sum of resistance distances between all pairs of vertices of G in electrical networks. LEL(G) is the Laplacian-Energy-Like Invariant of G in chemistry.
Pengli Lu, Ke Gao, Yang Yang
doaj   +1 more source

DIMENSI METRIK PADA GRAF Rn(q; r)m

open access: yesJurnal Matematika UNAND, 2019
The metric dimension of a connected graph G is the cardinality of minimum resolving set in graph G. In this research, how to find the metric dimension of Rn(q; r)m graph. Rn(q; r)m graph is constructing by subdivision operation on Lobster graph Ln(q; r).
Rendy Aditya Pratama   +2 more
doaj   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

open access: yesAdvanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser   +6 more
wiley   +1 more source

Deep Learning–Based Extraction of Promising Material Groups and Common Features from High‐Dimensional Data: A Case of Optical Spectra of Inorganic Crystals

open access: yesAdvanced Intelligent Discovery, EarlyView.
We report a novel interpretation method for deep learning models based on feature extraction and clustering. Applying this method to an atomistic line graph neural network (ALIGNN) model trained on optical absorption spectra of 2,681 inorganic compounds obtained from first‐principles calculations, we successfully identify key factors underlying ...
Akira Takahashi   +3 more
wiley   +1 more source

Topological Indices of the Line Graph of Subdivision Graph of Complete Bipartite Graphs [PDF]

open access: yes, 2017
Topological index is a number associated with molecular graph and this number correlate certain physico-chemical properties of chemical compounds.
Luis Garcıa Guirao, Juan   +7 more
core   +1 more source

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