TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala
British Journal of Pharmacology, EarlyView.Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi +12 more
wiley +1 more source
A two-timepoint framework for sensitive and specific single-cell activity screening. [PDF]
NeuronRamirez A +11 more
europepmc +1 more source
Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents
British Journal of Pharmacology, EarlyView.Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić +10 more
wiley +1 more source
Surgical delay is not associated with increased mortality in Greenlandic hip fracture patients: a 5-year retrospective cohort study. [PDF]
Int J Circumpolar HealthHansen EC +4 more
europepmc +1 more source
Cancer Science, EarlyView.This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen +17 more
wiley +1 more source
Treatment trajectories and patterns following non-medical switching to biosimilar adalimumab in patients with hidradenitis suppurativa: a retrospective observational multicenter study from Saudi Arabia. [PDF]
Future Sci OAAlamer A +4 more
europepmc +1 more source
Cancer Science, EarlyView.tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley +1 more source
Efferent projections of topographically distinct relaxin family peptide receptor-3 (RXFP3) lateral hypothalamus/zona incerta cells. [PDF]
Brain Struct FunctRichards BK +5 more
europepmc +1 more source
Cancer Science, EarlyView.Nationwide real‐world profiling revealed distinct clinicogenomic contexts across major BRAF alteration classes in gliomas and glioneuronal tumors. KIAA1549::BRAF fusion was associated with younger age and predominantly low‐grade tumors, whereas BRAF amplification‐only tumors were predominantly high‐grade and showed frequent MET amplification.
Seiji Yamada +7 more
wiley +1 more source
Rainfall-driven dynamics of faecal pollution in river bathing sites: coupling hydrological events, and DNA-assisted tracking to improve pollution management in recreational waters. [PDF]
Front MicrobiolDouterelo I +5 more
europepmc +1 more source