Results 131 to 140 of about 537,107 (230)

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

The Impact of Intraoperative Fibrinogen Replacement Therapy on the Clinical Outcome of Surgical Therapy for Type A Acute Aortic Dissection. [PDF]

Interdiscip Cardiovasc Thorac Surg
Takehara M, Shimamoto T, Sakamoto K, Hidaka Y, Muramatsu Y, Minatoya K.   +5 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Health care epidemiology, characteristics, and regional variation of chiropractic care in Switzerland: a descriptive study using insurance claims data. [PDF]

BMC Health Serv Res
Muñoz Laguna J, Rohner LS, Mühlemann M, Signorell A, Rosella LC, Puhan MA, Hincapié CA.   +6 more
europepmc   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

A Biomarker-Based Dose-Schedule Optimization Design for Immunotherapy Trials. [PDF]

Stat Med
Qiu Y, Han Y, Guo B.
europepmc   +1 more source

Takeover Vulnerability and the Discipline of ESG Overinvestment

Business Strategy and the Environment, EarlyView.
ABSTRACT While takeovers serve a disciplinary role by replacing inefficient managers, the threat of takeovers may compel firms to divert attention from Environmental, Social and Governance (ESG) efforts as a strategic response to external pressure, especially when such firms are already overinvesting in ESG.
Abongeh Tunyi, Ruth O. Sagay, Reon Matemane   +2 more
wiley   +1 more source

Real-world efficacy and tolerability of ixazomib-based combination therapies in advanced multiple myeloma and other plasma cell neoplasms. [PDF]

Ther Adv Hematol
Zhou X, Mersi J, Riedhammer C, Steinhardt MJ, Bittrich M, Knop S, Einsele H, Rasche L, Kortüm KM, Waldschmidt JM.   +9 more
europepmc   +1 more source

Adolescent Cyberviolence in South Korea: A Multi‐Year, National Population‐Based Study of Cyberviolence Prevalence (2017–2024)

Behavioral Sciences &the Law, EarlyView.
ABSTRACT With the rise of digital technology, adolescent cyberviolence has become a growing global concern in public health and criminal justice. This study used nationally representative data from South Korea (2017–2024) to examine the prevalence of eight types of cyberviolence (i.e., verbal abuse, defamation, stalking, sexual abuse, personal ...
Heng Choon (Oliver) Chan, Hong‐Jun Park, Evelyn Svingen   +2 more
wiley   +1 more source

Patient-reported outcomes after hysterectomy due to pelvic organ prolapse versus other indications - a 10-year national follow-up study. [PDF]

BMC Womens Health
Kuittinen T, Tulokas S, Rahkola-Soisalo P, Brummer T, Härkki P, Mentula M.   +5 more
europepmc   +1 more source