Results 41 to 50 of about 537,107 (230)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

On the Chabauty space of locally compact abelian groups

, 2010
This paper contains several results about the Chabauty space of a general locally compact abelian group. Notably, we determine its topological dimension, we characterize when it is totally disconnected or connected; we characterize isolated points ...
Bourbaki, Bourbaki, Chabauty, Dixmier, Engelking, Grigorchuk, Hurewicz, Isbell, Mahler, Pasynkov, Protasov, Protasov, Protasov, Vopěnka, Wattenberg, Yves Cornulier   +15 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

The evolution and expansion of RWP-RK gene family improve the heat adaptability of elephant grass (Pennisetum purpureum Schum.)

BMC Genomics, 2023
Background Along with global warming, resulting in crop production, exacerbating the global food crisis. Therefore, it is urgent to study the mechanism of plant heat resistance.
Yarong Jin, Jinchan Luo, Yuchen Yang, Jiyuan Jia, Min Sun, Xiaoshan Wang, Imran Khan, Dejun Huang, Linkai Huang   +8 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

A Combination Theorem for Convex Hyperbolic Manifolds, with Applications to Surfaces in 3-Manifolds

, 2005
We prove the convex combination theorem for hyperbolic n-manifolds. Applications are given both in high dimensions and in 3 dimensions. One consequence is that given two geometrically finite subgroups of a discrete group of isometries of hyperbolic n ...
Agol, Baker, Baker, Bestvina, Bowditch, Bowditch, Cooper, Cooper, Cooper, Culler, Culler, Dahmani, Daryl Cooper, Freedman, Gitik, Gitik, Gitik, Hass, Hass, Hatcher, Hempel, Kang, Long, Maher, Malcev, Mark Baker, Maskit, Masters, Oertel, Scott, Susskind, Susskind, Susskind, Thurston   +33 more
core   +5 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Non-invasive hemodynamic monitoring in the acute period of polytrauma as a method to control and correction respiratory and circulatory disorders

Ендоваскулярна нейрорентгенохірургія, 2019
Objective – to establish the value of non-invasive monitoring of central hemodynamics during the acute period of polytrauma and its impact on systemic respiratory and circulatory parameters and intensive care treatment using the estimated Continuous ...
N.W. Matolinets, Ya.M Pidhirnyy, A.M. Netliukh   +2 more
doaj   +1 more source

Elementary amenable subgroups of R. Thompson's group F

, 2005
The subgroup structure of Thompson's group F is not yet fully understood. The group F is a subgroup of the group PL(I) of orientation preserving, piecewise linear self homeomorphisms of the unit interval and this larger group thus also has a poorly ...
Adyan S. I., Cannon J. W., Chou C., Cleary S., Day M. M., Dydak J., Dydak J., Grigorchuk R. I., Guba V., Kaloujnine L., MATTHEW G. BRIN, Ol′šanskiĭ A. Ju., Wagon S.   +12 more
core   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source