Results 71 to 80 of about 147,914 (261)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Some Partial Considerations on Partial Control Instances in Romanian
LingBaWThe paper looks at the possibility of Partial Control (henceforth, PC) instances in Romanian, a language which uses finite (subjunctive) complements in typical control contexts and where PC has therefore been deemed impossible.
Maria Aurelia Cotfas
doaj +1 more source
Subject Knowledge Evaluation Method for Language Models Based on Multiple ChoiceQuestions [PDF]
Jisuanji kexueSubject knowledge evaluation methods for pre-trained language models based on Multiple Choice Questions(MCQ) offer rapid,quantitative evaluation of model knowledge.However,their reliability is compromised by irrelevant factors such as option order and ...
XIONG Zhuozhi, GU Zhouhong, FENG Hongwei, XIAO Yanghua
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
PERILAKU SUBJEK DALAM BAHASA KEMAK KABUPATEN BELU NUSA TENGGARA TIMUR
Litera, 2016 This study aims to identify subject characteristics of the Kemak language in Belu Regency, East Nusa Tenggara. The subject characteristics are identified by testing the arguments predicted as a subject.
I Wayan Budiarta
doaj
IMPLEMENTASI PEMBELAJARAN INKUIRI PADA BIDANG STUDI AQIDAH AKHLAK
Potensia, 2017 This research raises the problem of the implementation of inquiry learning in the aqidah akhlak subject in Madrasah Aliyah Muhammadiyah Pekanbaru, by raising the research question: how to implement inquiry learning in the aqidah akhlak subject in ...
Sariah Sariah
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Harm Reduction JournalAim The purpose of this study was to explore Muslim’s perceptions and views of raising awareness on safe alcohol use and counterfeit alcohol harms in Islamic countries.
Samah Alageel, Noura Alomair
doaj +1 more source