Results 191 to 200 of about 2,755,392 (247)

Skin characteristics of photoaging and intrinsic aging in Southwest Chinese population: a reflectance confocal microscopy and histopathological study. [PDF]

Front Physiol
Cao G, Chen Y, Guan S, Chen L, Yu R, Chen A.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Genotypic and phenotypic spectrum of Galloway-Mowat syndrome in Kuwait. [PDF]

Glob Med Genet
Alhammad F, Ali NY, Alkanderi S, Elshafie RM, Bastaki L, Albash B, Alsharhan H, Marafi D.   +7 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Integrative analysis of left ventricle and epicardial adipose tissue identifies SDHA and OGDH as candidate targets for ischemic heart disease. [PDF]

iScience
Arif M, Doran S, Clausen M, Wikström J, Bohlooly-Y M, Björnson E, Davidsson L, Jeppsson A, Levin M, Mardinoglu A, Boren J.   +10 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Automatic Item Generation Measurement Models Respecting the Stochastic Sampling Space for Cross-Classified and Two-Level Sampling of Subjects and Incidentals. [PDF]

Appl Psychol Meas
Jahn P, Jendryczko D, Nussbeck FW.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Clinically relevant change in airway wall thickness to identify disease activity in COPD and smokers at risk. [PDF]

Eur Respir J
Abdo M, Reck M, Stiebeler S, Bollmann BA, Bohnet S, May K, Dettmer S, Watz H, Vogel-Claussen J, HANSE Trial Group.   +9 more
europepmc   +1 more source