Results 41 to 50 of about 34,245 (309)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Comparing Aggradation, Superelevation, and Avulsion Frequency of Submarine and Fluvial Channels

Frontiers in Earth Science, 2020
Constraining the avulsion dynamics of rivers and submarine channels is essential for predicting the distribution of sediment, organic matter, and pollutants in alluvial, deltaic, and submarine settings.
Zane R. Jobe, Nick C. Howes, Kyle M. Straub, Dingxin Cai, Hang Deng, Fabien J. Laugier, Luke A. Pettinga, Lauren E. Shumaker   +7 more
doaj   +1 more source

Typical gravity flow sedimentary features and provenance system in Yinggehai-Qiongdongnan Basin, northern South China Sea

地质科技通报, 2022
This study reviewed the sedimentary characteristics and formation mechanism of the Yinggehai-Qiongdongnan Basin based on the lateral sedimentary distribution, vertical sedimentary sequence, and dynamic sedimentary process.
Hua Wang, Si Chen, Entao Liu, Jie He, Huajun Gan, Fulin Meng, Weihao Nian   +6 more
doaj   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Cenozoic sedimentary and volcanic rocks of New Zealand: A reference volume of lithology, age and paleoenvironments with maps (PMAPs) and database. [PDF]

, 2015
This volume presents descriptive geological data and text about each Cenozoic sedimentary and volcanic geological unit to formation and member level (in some cases) exposed on land in New Zealand, including their lithology, stratigraphic age and inferred
Kamp, Peter J.J., Tayler, Michael J.S., Vincent, Kirsty A.   +2 more
core   +1 more source

Magnetic Characterization of Sediment Source‐To‐Sink Processes in the Bengal Fan Since 45 ka

Geochemistry, Geophysics, Geosystems
The Bengal Fan is the largest submarine fan on Earth with a complex submarine channel system. Therefore, it is challenging to understand the evolution of Bengal Fan sediment source‐to‐sink processes.
Rong Huang, Liao Chang, Shishun Wang, Pengfei Xue, Shengfa Liu, Xuefa Shi, Somkiat Khokiattiwong, Narumol Kornkanitnan   +7 more
doaj   +1 more source

How is particulate organic carbon transported through the river-fed submarine Congo Canyon to the deep sea? [PDF]

Biogeosciences
The transfer of carbon from land to the near-coastal ocean is increasingly being recognized in global carbon budgets. However, a more direct transfer of terrestrial organic carbon to the deep sea is comparatively overlooked.
S. Hage, M. L. Baker, N. Babonneau, G. Soulet, B. Dennielou, R. Silva Jacinto, R. G. Hilton, V. Galy, F. Baudin, C. Rabouille, C. Vic, S. Sahin, S. Açikalin, P. J. Talling   +13 more
doaj   +1 more source

Source-to-sink system and sedimentary characteristics of the lower Miocene submarine fans in the eastern deepwater area of the Qiongdongnan Basin, northern South China Sea

Frontiers in Earth Science, 2022
As the main target of deepwater oil and gas exploration, submarine fans are also the frontier and focus of sedimentology research. Based on the latest three-dimensional (3D) seismic data covering the study area, as well as heavy mineral, rare earth ...
Rui Sun, Xingzong Yao, Xiayang Wang, Keqiang Wu, Yinxue Han, Jianyong Xu, Haizhang Yang, Hongyi Li, Qingbo Zeng, Zezhang Song, Zezhang Song   +10 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source