Results 181 to 190 of about 472,437 (333)
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan +9 more
wiley +1 more source
Advances and challenges in oil and gas pipeline pigging technology: a comprehensive review. [PDF]
Hu Z, Zhang Y, Liu Q, Liu B, Zhao L.
europepmc +1 more source
Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang +3 more
wiley +1 more source
Full-Scale Testing of Corrosion Resistant Alloy-Mechanically Lined Pipes for Submarine Pipelines [PDF]
Ahmed Reda +4 more
openalex +1 more source
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao +14 more
wiley +1 more source
An adaptive multi-scale kriging framework with committee-based infill for engineering design optimization. [PDF]
Xie H, Zhong Q, Zeng W.
europepmc +1 more source
Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley +1 more source

