Results 71 to 80 of about 1,126 (256)

The thermal properties of submarine rhyolite lavas from Havre volcano (Kermadec arc, Pacific Ocean)

Volcanica
The thermal properties of lavas are required for modelling volcanic and hydrothermal processes, yet are scarce for submarine lavas. Laboratory experiments, using the transient hot-strip method, are used to understand the role of porosity, glass content ...
Rebecca Carey, Michael Heap, Samuel Mitchell, Fabian Wadsworth   +3 more
doaj   +1 more source

IMPACT AND RESPONSE IN CENTRAL AND SOUTH AMERICA DUE TO THE TSUNAMI GENERATED BY THE SUBMARINE ERUPTION OF HUNGA TONGA-HUNGA HA’APAI VOLCANO [PDF]

Science of Tsunami Hazards, 2022
Th Hunga Tonga-Hunga Ha'apai submarine volcano erupted on Saturday 15, 2022 leading to a VEI 5 eruption at 17.27 local time, shaking the earth with a M5.8. As result of this explosion a tsunami was triggered.
Theofilos Toulkeridis, Noris Martinez, Willington Rentería, Gustavo Barrantes, Grey Barragan-Aroca, Débora Simón-Baile, Iván Palacios, Rodolfo Salazar, Elkin de Jesús Salcedo-Hurtado, George Pararas-Carayannis   +9 more
doaj  

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Origin of Fluid in Submarine Mud Volcanoes

Chigaku Zasshi (Jounal of Geography), 2009
Submarine mud volcanoes are remarkable geological features on the seafloor, which are probably formed by mud breccia extruded from sub-seafloor sediment layers to the seafloor. Most of such volcanoes are found near the continental margin. The driving force of mud volcanism is thought to be unusually high pressure within the deep sedimentary layer and ...
openaire   +2 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

The Evolution of Gajahmungkur Paleovolcano, Wonogiri, Central Java, as A Reference to Revize the Terminology of “Old Andesite Formation”

Indonesian Journal on Geoscience, 2014
DOI: 10.17014/ijog.v5i4.109Gajahmungkur is a Tertiary paleovolcano located in Wonogiri Regency, Central Java. The volcanic product of this volcano are widely distributed and composed of important elements of the stratigraphic sequence in the Southern ...
Ildrem Syafri, A. Sudradjat, Nana Sulaksana, G. Hartono   +3 more
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Gumuk gunung api purba bawah laut di Tawangsari - Jomboran, Sukoharjo - Wonogiri, Jawa Tengah

Indonesian Journal on Geoscience, 2014
http://dx.doi.org/10.17014/ijog.vol3no1.20084This paper discusses the study on the basalt volcanic rocks and the volcano morphology indicating the existence of an ancient submarine volcano in Tawangsari-Jomboran sub-regency, Sukoharjo- Wonogiri, Central ...
Gendoet Hartono, Adjat Sudrajat, Ildrem Syafri   +2 more
doaj   +1 more source