Results 81 to 90 of about 226,603 (334)

Improving the life of people with co-existing mental health disorders and substance misuse problems [PDF]

, 2016
There is a strong connection between mental health and substance use. Substances can trigger or exacerbate reexisting psychiatric problems and psychiatric symptoms can develop as a result of withdrawals after drug and alcohol intoxication.
Milani, Raffaella Margherita
core  

Codeine misuse and dependence in South Africa – learning from substance abuse treatment admissions [PDF]

, 2015
Background. Misuse of prescription and over-the-counter codeine-containing products is a global public health issue. Objectives. To investigate the extent of treatment demand related to the misuse of codeine or codeine dependence in South Africa (SA) and
Burnhams, NH, Dada, S, Parry, CDH, van Hout, MC   +3 more
core   +4 more sources

Pregabalin misuse: A silent epidemic

Sri Lanka Journal of Psychiatry, 2019
Pregabalin is used to treat numerous conditions ranging from peripheral neuropathy to social phobia. Multiple case reports of its abuse potential and dependence, including withdrawal symptoms, have being published in the world literature.
A. Hapangama, K. A. L. A. Kuruppuarachchi   +1 more
doaj   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

The impact of substance use on brain structure in people at high risk of developing schizophrenia [PDF]

, 2010
Ventricular enlargement and reduced prefrontal volume are consistent findings in schizophrenia. Both are present in first episode subjects and may be detectable before the onset of clinical disorder.
Agartz, Andrew M. McIntosh, Bangalore, Berman, Boos, Cantwell, Chambers, David G.C. Owens, De Bellis, De Bellis, Dickey, Dominic E. Job, Drake, Eve C. Johnstone, Fein, Gouzoulis-Mayfrank, Heather C. Whalley, Hodges, Howes, Jeremy Hall, Job, Job, Johnstone, Johnstone, Killian A. Welch, Kril, Lawrie, Lawrie, Margolese, Martín-Santos, Mathalon, McCreadie, Medina, Moore, Mueser, Pfefferbaum, Pfefferbaum, Picchioni, Potvin, Quickfall, Rais, Scottish Government, Semple, Shenton, Smit, Soyka, Stephen M. Lawrie, Suddath, Sullivan, Sullivan, Sullivan, Szeszko, Thomas W. Moorhead, Thompson, Wechsler, Whalley, Wright, Zammit   +57 more
core   +2 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Implementing personal health budgets in England: A user-led approach to substance misuse [PDF]

, 2016
Personal health budgets (PHBs) in England have been viewed as a vehicle for developing a personalised patient-based strategy within the substance misuse care pathway. In 2009, the Department of Health announced a 3-year pilot programme of PHBs to explore
Allen, Amato, Bamford, Beecham, Boyle, Castells, Davidson, Department of Health, Forder, Hamilton, Hamilton, Higgs, HM Government, Irvine, Jones, Larsen, Larsen, Magill, National Institute for Health and Clinical Excellence, National Treatment Agency for Substance Misuse, NTA, ONS, PHE, Royal Society for the Encouragement of Arts, Manufactures and Commerce, Tew, The Social Care Institute for Excellence, Thomas, Turton, Welch   +28 more
core   +3 more sources

Factors that could contribute to substance misuse and criminal activity amongst adolescents : an ecological perspective

Social Work/Maatskaplike Werk, 2019
The increase of criminal behaviour and substance misuse amongst adolescents is of great concern for social service providers. According to the ecological perspective, several factors could contribute to substance misuse and criminal activity amongst ...
Jacobs, Tasneem , Slabbert, Ilze
doaj   +1 more source

Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”

Advanced Science, EarlyView.
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner, Nina Claessens, Caitlin M. Maloney, Peter Claes   +3 more
wiley   +1 more source

Cross-sectional Associations of Opiate Misuse/Opioid Use Disorder among Adults Experiencing Homelessness

Health Behavior Research, 2019
The purpose of this manuscript is to determine the prevalence of opioid misuse/opioid use disorder (OUD) among adults experiencing homelessness and describe characteristics that account for significant variance in relation to opioid misuse in those who ...
Valentina Maza, Daphne C. Hernandez, Darla E. Kendzor, Michael S. Businelle   +3 more
doaj   +1 more source