Results 231 to 240 of about 373,515 (298)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The strategic distraction motive: addiction as attentional regulation under perceived insolubility. [PDF]

Front Psychol
Alaye FA, Gelo O, Unterrainer HF.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

HIV and Substance Use Reduction for Youth Experiencing Homelessness: Development and Usability Study. [PDF]

JMIR Form Res
Santa Maria D, Businelle M, Slesnick N, Padhye N, Harrison T, Ging L, Jones JDT, White M.   +7 more
europepmc   +1 more source

Cytisine-New Challenges of a Well-Known Drug in the Treatment of Nicotine Addiction. [PDF]

J Clin Med
Bieniasz L, Wróblewski K, Kamizela A, Szyszkowska A, Grzegorzewski W, Czerniecka-Kubicka A.   +5 more
europepmc   +1 more source

Stigma toward individuals with cannabis use disorder across age groups: associations with familiarity and sociodemographic characteristics. [PDF]

Harm Reduct J
Basedow LA, Wandinger E, Brindle A, Kölch M, Reis O.   +4 more
europepmc   +1 more source

Multilevel associations between skills use, engagement, and treatment outcome in self-guided internet-delivered dialectical behavior therapy for substance use disorders. [PDF]

PLOS Ment Health
Downie D, Daros AR, Wilks CR, Quilty LC.
europepmc   +1 more source

A Daily Diary Study of Discrimination and Substance Use in Transgender and Nonbinary Adults. [PDF]

Psychol Sex Orientat Gend Divers
Basting EJ, Garner AR, Munson M, Shorey RC, Stuart GL.   +4 more
europepmc   +1 more source

Faktische Organe im Zivilprozess – Substance over Form?

, 2016
openaire   +1 more source

Securitisation disclosures and compliance under Basel II: part II - applications of the risk symmetry principle to economic substance over legal form

, 2006
Tanega, J.
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