Leveraging Large Language Models to Analyze Emotional and Contextual Drivers of Teen Substance Use in Online Discussions [PDF]
arXivAdolescence is a critical stage often linked to risky behaviors, including substance use, with significant developmental and public health implications. Social media provides a lens into adolescent self-expression, but interpreting emotional and contextual signals remains complex.
arxiv
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
CORRELATES OF SUBSTANCE USE DISORDER AMONG PSYCHIATRIC OUTPATIENTS: FOCUS ON COGNITION, SOCIAL ROLE FUNCTIONING, AND PSYCHIATRIC STATUS [PDF]
, 2003 Kate B. Carey +2 more
openalex +1 more source
Patient registries for substance use disorders
Substance Abuse and Rehabilitation, 2014 Betty Tai,1 Lian Hu,2 Udi E Ghitza,1 Steven Sparenborg,1 Paul VanVeldhuisen,2 Robert Lindblad2 1Center for the Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA; 2The EMMES Corporation, Rockville,
Tai B +5 more
doaj
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Comparison of the prevalence of substance use and psychiatric disorders between government‐ and self‐employed commercial drivers [PDF]
, 2003 Shih‐Ku Lin +3 more
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Bridging the Divide White Paper: Pregnant Women and Substance Use: Overview of Research & Policy in the United States [PDF]
, 2017 This paper examines the current literature and policy implications of substance use and substance use disorders among pregnant and parenting women. While this is not meant to serve as an exhaustive literature review on this topic, it seeks to describe ...
Allina, Amy +5 more
core +1 more source
Absolute Risk Prediction for Cannabis Use Disorder in Adolescence and Early Adulthood Using Bayesian Machine Learning [PDF]
arXivIntroduction: Substance use disorders (SUDs) have emerged as a pressing public health concern in the United States, with adolescent substance use often leading to SUDs in adulthood. Effective strategies are needed to stem this progression. To help fulfill this need, we developed a novel absolute risk prediction model for cannabis use disorder (CUD) for
arxiv
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
The evaluation of treatment services and systems for substance use disorders [PDF]
, 2003 Brian Rush
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