Results 181 to 190 of about 1,609,846 (283)

Silence-Embedded Distress: A Case Report Conceptualizing a Culturally Mediated Trauma Phenomenon in Community-Based Mental Health Practice in Rwanda. [PDF]

Clin Case Rep
Gashugi Y.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Foundation for Artificial Intelligence-Driven Democratization of Healthcare Access. [PDF]

Learn Health Syst
Reddy S.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Confirmatory Person-Oriented Mediation Analysis in Categorical Variables-Options and Limitations. [PDF]

Integr Psychol Behav Sci
Eye AV, Wiedermann W.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The substantive representation of women in the Tanzanian parliament

, 2011
The thesis investigates if the use of a reserve seat system of parliamentary quotas that has produced a substantial descriptive increase in the number of women in the Tanzanian parliament has translated into substantive representation for women in terms of either process or outcome. It utilized the Tanzanian parliamentary database as its primary source
openaire   +1 more source

Peri-lymphatic cytokines (IRX-2) as immunologic induction preceding neoadjuvant chemo-immunotherapy in triple-negative breast cancer. [PDF]

NPJ Breast Cancer
Su A, Hong EC, Moxon N, Mellinger SL, Kelly T, Conlin AK, Topp ZZ, Newell P, Fredrich N, Massimino KP, Wu Y, Martel M, Redmond WL, Aliabadi-Wahle S, Sun Z, Imatani J, Stanton SE, Hanes DA, Simanonok M, Rosales W, Nielsen TJ, Page DB.   +21 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

District magnitude and substantive representation

Irish Political Studies
openaire   +3 more sources