Results 221 to 230 of about 4,269,200 (246)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10-day bed rest in older adults. [PDF]

J Physiol
Motanova E, Zuccarelli L, Lysenko E, Amoretti S, Pirazzini M, Rossetto O, Brocca L, Bottinelli R, Pellegrino MA, Baldassarre G, Gissi C, Lippe G, Gasparini M, Šimunic B, Pišot R, Grassi B, Narici MV.   +16 more
europepmc   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

Phosphorus addition shifts elevated CO₂ effects on soil respiration from rhizosphere to root pathways in a mature eucalypt woodland. [PDF]

New Phytol
Zhao M, Jiang Q, Macdonald CA, Tissue DT, Wen W, Piñeiro J, Noh NJ, Pendall E, Smith B, Ellsworth DS, Jiang M, Medlyn BE.   +11 more
europepmc   +1 more source

Cardiometabolic stress induces HFpEF with impaired bioenergetics and disrupted proteostasis in aged female mice. [PDF]

J Mol Cell Cardiol
Kobak KA, Zarzycka W, King CJ, Peelor FF, Burnett C, Freeman WM, Humphries KM, Miller BF, Chiao YA.   +8 more
europepmc   +1 more source

Establishing a direct interaction between the 19,20-EDP analog SA-22 and SIRT3: impact on cardiac mitochondrial homeostasis. [PDF]

Front Pharmacol
Kranrod JW, Valencia R, Heidari M, Ibrahim KM, Adebesin AM, Munnuri S, Falck JR, Seubert JM.   +7 more
europepmc   +1 more source

Gut-derived metabolites and mitochondrial homeostasis in heart failure: mechanistic links and translational perspectives. [PDF]

Front Cardiovasc Med
Chen D, Su M, Xie Z, Xu S, Luo S.
europepmc   +1 more source

From metabolism to neurodegeneration: how microglial functional reprogramming drives neurodegenerative diseases. [PDF]

Front Mol Neurosci
Cui Q, Zheng K, Liu Q, Wang L, Liu Y, Bai R, Zhang W, Guo J, Chang X, Wang J.   +9 more
europepmc   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity. [PDF]

Adv Sci (Weinh)
Strehlau C, Broghammer H, Gebhardt C, Hoffmann A, Hagemann T, Midilli Ş, Zimmer RS, Schubert K, Karagiannakou V, Georgiadi A, Ost M, Krüger M, Roth L, Krause K, Klöting N, Keller M, Wabitsch M, Nuwayhid R, Stimson RH, Stumvoll M, Blüher M, Weiner J, Heiker JT.   +22 more
europepmc   +1 more source

An evaluation of the substrate-induced respiration method [PDF]

Soil Biology and Biochemistry, 1999
P C Brookes
exaly   +1 more source