Results 51 to 60 of about 4,269,200 (246)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Carbon of microbial biomass in Al-Fe-humus soils of the northwestern Russia

Бюллетень Почвенного института им. В.В. Докучаева
The study was carried out in blueberry pine forests of the middle taiga subzone of Karelia. The results of complex studies of the microbiocenosis of Al-Fe-humus soils (Albic Podzols) formed on fluvioglacial deposits are presented.
M. V. Medvedeva, D. A. Nikitin, M. V. Semenov, G. V. Akhmetova   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Material Collected From the Induced Seismicity State Task Force Meeting, Wednesday, April 16, 2014, Newman University, Wichita, Kansas

, 2014
Announcement -- Agenda -- Breakout Sessions: Questions and Responses -- An Ounce of Understanding is Worth a Pound of Cure / by Kyle E. Murray -- Induced Seismicity and the Oil and Gas Industry -- Overview of Kansas Earthquakes / Rick Miller, Shelby ...
Induced Seismicity State Task Force Meeting (2014 : Wichita, Kan.)
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Biodynamic compost effects on soil parameters in a 27-year long-term field experiment

Chemical and Biological Technologies in Agriculture, 2022
Background Soil samples were taken after 27 years from a long-term field experiment to study the effects of composted pure cattle farmyard manure (FYM) and two FYM treatments with biodynamic preparations on soil chemical and microbiological properties ...
Heberto Rodas-Gaitan, Jürgen Fritz, Christian Dahn, Ulrich Köpke, Rainer Georg Joergensen   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer

iScience, 2020
Summary: The epidemiological association between disrupted circadian rhythms and metabolic diseases is implicated in increased risk of human breast cancer and poor therapeutic outcomes.
Cassandra A. Ramos, Ching Ouyang, Yue Qi, Yiyin Chung, Chun-Ting Cheng, Mark A. LaBarge, Victoria L. Seewaldt, David K. Ann   +7 more
doaj   +1 more source

Zooplankton respiration

, 2007
This chapter reviews metazooplankton (>200 μm) respiration in aquatic systems. It discusses methodology, modifying agents (physical, chemical, and biological factors), definitions, and carbon equivalents. The major determinants of zooplankton respiration
Hernández-León, Santiago, Ikeda, Tsutomu   +1 more
core   +1 more source

Bomb-14C analysis of ecosystem respiration reveals that peatland vegetation facilitates release of old carbon [PDF]

, 2009
The largest terrestrial-to-atmosphere carbon flux is respired CO2. However, the partitioning of soil and plant sources, understanding of contributory mechanisms, and their response to climate change are uncertain.
Fallick, A. E., Fallick, A.E., Ostle, N.J., Hardie, S.M.L., Garnett, M.H., Rowland, A. P., Rowland, A.P., Hardie, S. M.L., Garnett, M. H., Ostle, N. J.   +9 more
core   +1 more source