Results 111 to 120 of about 68,610 (251)

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Energy substrate preference and metabolic flexibility in quiescent and oxytocin-stimulated human myometrial cells. [PDF]

iScience
Prifti KK, Dave RM, Mitchum KT, Rich JL, Gill RM, Mbadhi MN, Frolova AI.   +6 more
europepmc   +1 more source

Multiple Substrate-Induced Respiration and Isothermal Calorimetry : Applicability in Risk Assessment of Contaminated Soil

, 2017
At present, soils face great threats. Consequences of human activities, such as climate change, acidification and contamination result in decreased soil health. This is a threat to human health and well-being, since our society is dependent on soil ecosystem services.
openaire   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Inhibitory Effect of ATP on Cytochrome c Oxidase Depends on Electron Entry Pathways by TCA Cycle Metabolites. [PDF]

Cells
Günther M, Pakic V, Weber P, Veit A, Culmsee C, Rastan AJ, Busch AP, Vogt S.   +7 more
europepmc   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions. [PDF]

FEBS Lett
Debska-Vielhaber G, Karavasili N, Kunz M, Gizatullina Z, Gainutdinov T, Vielhaber S, Kunz WS, Gellerich FN.   +7 more
europepmc   +1 more source

A Crack‐Based One‐Dimensional Microspheres Array Enables Thermal–Mechanical Decoupled Dual‐Functional Sensing

Advanced Science, EarlyView.
Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu, Hongyi Tu, Zehao Wang, Tianyu Zhu, Chao Wang, Min Chen, Lan Shi, Limin Wu   +7 more
wiley   +1 more source

Patient-derived glioblastoma cultures preserve respiration phenotypes during ex vivo maintenance and show sex-associated differences in migration. [PDF]

Acta Neuropathol Commun
Matschke V, Glover P, Lucaciu R, Pickmann D, Scholz M, Theiss C, Hoffmann D, Matschke J.   +7 more
europepmc   +1 more source