Results 191 to 200 of about 68,610 (251)

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Wheat leaf dark respiration acclimates more strongly at night than in the day when responding to nocturnal warming. [PDF]

J Exp Bot
Rana Shahi P, Scafaro AP, Thistlethwaite RJ, Atkin OK, Trethowan RM, Rader R, Burns A, Coast O.   +7 more
europepmc   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Pro- and Anti-Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites. [PDF]

Eur J Immunol
Nasirzade J, Sternberg F, Vogel A, Sango R, Beikbaghban T, Kolbe T, Rattei T, Weichhart T, Pohl EE.   +8 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Nitrogen Mustard Disrupts Bioenergetics and Activates Oxidative Stress-Induced Cell Death Pathways in Human Keratinocytes. [PDF]

Chem Res Toxicol
Jan YH, Michniak-Kohn B, Joseph LB, Laskin DL, Laskin JD.   +4 more
europepmc   +1 more source

Exploring Replicative Senescence and Oxidative Stress-Induced Remodelling of Mitochondrial-Associated Membranes in Human Skin Fibroblasts. [PDF]

Biomolecules
Bulteau AL, Beauchef G, Chanon S, Vieille-Marchis A, Chlasta J, Runel G, Sage J, Naiken T, Sobilo L, Bossard E, Gourguillon L, Nizard C, Pays K, Canaple L, Morio B.   +14 more
europepmc   +1 more source

Clean cut to curtail respiration: OMA1 cleaves AIFM1 to tune stress-induced bioenergetics. [PDF]

EMBO J
Afridi MI, Chacinska A.
europepmc   +1 more source

Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications. [PDF]

Redox Biol
Chinopoulos C.
europepmc   +1 more source