Results 131 to 140 of about 1,936,726 (258)

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases. [PDF]

Sci Adv
Mortensen S, Burnim AA, Dufault-Thompson K, Lipka AE, Jiang X, Sondermann H.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Graph neural networks can predict ketosynthase substrate specificity. [PDF]

Sci Rep
Walmsley M, Connolly JA, Takano E, Breitling R.   +3 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Substrate Specificity and Kinetic Mechanism of the NAD+-Dependent Deacylase from Mycobacterium tuberculosis, Rv1151c (Mt-Sirt). [PDF]

Biochemistry
Mellott DM, Zhu J, Fulcher H, Meek TD.
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Cleavage of MEP-1 by DPF-3 reveals novel substrate specificity and its impact on reproductive fitness. [PDF]

EMBO Rep
Aygün I, Amanullah A, Seebacher J, Hess D, Soneson C, Roy A, Großhans H, Gudipati RK.   +7 more
europepmc   +2 more sources

Structure-activity relationship study shows versatility in substrate specificity for heterodisulfide reductase in methanogenic archaea. [PDF]

Protein Sci
Maleki MF, Jakobsen JB, Schuiten ED, Wagner T, Neves ALA, Bunch L.   +5 more
europepmc   +1 more source

Substrate specificity of amine oxidases [PDF]

Biochemical Journal, 1945
H, Blaschko, R, Duthie
openaire   +2 more sources