Results 321 to 330 of about 792,149 (335)
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Substrate specificity of squalene synthetase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 198022 artificial homologues of farnesyl pyrophosphate were examined for the reactivity as substrate for squalene synthetase of pig liver microsomes. 16 of the homologues were found to be reactive to give corresponding squalene-like products. Extention of the omega-terminal of the carbon chain of farnesyl pyrophosphate is acceptable to the enzyme at least ...
Seto Shuichi +2 more
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Substrate Specificity of Peroxidase [PDF]
Science, 1955 Britton Chance, R. R. Fergusson
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Substrate specificity of pancreatic lipase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1968Abstract 1. 1. The hydrolysis of esters of oleic acid by pancreatic lipase (glycerol-ester hydrolase, EC 3.1.1.3) depends on the nature of the alcohol. Two factors appear to influence the speed of the reaction: an inductive effect, and steric hindrance. 2. 2.
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Substrate specificity of ascorbate oxidase
Biochemical and Biophysical Research Communications, 1976Abstract Ascorbate oxidase oxidizes leuco 2, 6-dichloroindophenol to the blue quinoid dye and produces spectral changes in the UV spectra of certain substituted polyhydric and amino phenols at pH 5.7. The new peaks produced by the addition of enzyme to the dichlorohydroquinones (2,5 and 2,6) and hydroxyhydroquinone correspond to the respective p ...
Charles R. Dawson, Jean Dayan
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[37] Substrate docking algorithms and the prediction of substrate specificity
1996Publisher Summary This chapter describes the substrate docking algorithms and the prediction of substrate specificity. The utility of computer-assisted molecular docking for the prediction of cytochrome P450 substrates has been explored. P450cam is used as the model P450 enzyme because several high resolution crystal structures are available for it ...
De Voss, James J. +1 more
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Substrate specificity of bleomycin hydrolase
Biochemical Pharmacology, 1989Bleomycin (BLM) hydrolase is believed to protect both malignant and normal tissue from the toxicity of the antitumor drug BLM. Little is known about the substrate specificity of BLM hydrolase. Thus, we developed ion-paired reverse phase high speed liquid chromatography systems to assay for the metabolism of several BLM analogs.
Sidney M. Hecht +4 more
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Substrate specificity of strictosidine synthase
Bioorganic & Medicinal Chemistry Letters, 2006Strictosidine synthase catalyzes a Pictet-Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic ...
McCoy, E, Galan , MC, O'Connor, SE
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Substrate specificity of vertebrate collagenase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1976Substrate specificity of purified tadpole collagenase (EC 3.4.24.3) has been studied using eleven synthetic peptides. A pentapeptide, t-butyloxycarbonylprolylalanylglycylisoleucylalanine amide, was susceptible to the action of the enzyme and an octapeptide, acetylprolylglutaminylglycylisoleucylalanylglycylglutaminylarginine ethyl ester, was proposed to
Yoshihiro Masui +2 more
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Specifying Substrate Specificity
Science Signaling, 2013Distinct intracellular signaling pathways acting on the substrates of a protease could determine which substrates are cleaved.
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Computation of enzyme-substrate specificity
Biochemistry, 1981The present study reports the development of a new procedure for teh theoretical computation of enzyme-substrate specificities. The immediate goal has been to identify experimental data with which computations may be effectively compared, examine the underlying theoretical principles, and demonstrate feasibility.
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