Results 41 to 50 of about 137 (130)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Constructive Logic with Strong Negation is a Substructural Logic. I [PDF]

Studia Logica, 2008
This is the latter half of two papers in which the authors show that the constructive logic with strong negation is definitionally equivalent to a certain axiomatic extension of the substructural logic FLew, namely, the full Lambek calculus with exchange and weakening. In the first half [\textit{M. Spinks} and \textit{R. Veroff}, Stud. Log. 88, No.
Matthew Spinks, Robert Veroff
openaire   +3 more sources

Deploying Soft Operations Research Techniques in Hybrid Modelling: The Role of Qualitative System Dynamics in Sustainability Analysis

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Organisations increasingly need modelling approaches that can support sustainable development decisions across economic, environmental and social dimensions. The triple bottom line (TBL) perspective provides a useful basis for such analysis, but it also introduces modelling challenges because the relevant dimensions are often interdependent ...
Masoud Fakhimi, Navonil Mustafee, Lampros Stergioulas   +2 more
wiley   +1 more source

Identification of Influencing Factors on Proenvironmental Behaviour and Construction of a Causal Loop Diagram

Systems Research and Behavioral Science, EarlyView.
ABSTRACT This study addresses the limitations of reductionist approaches to citizens' proenvironmental behaviour (PEB) by adopting a systems thinking perspective. Using qualitative system dynamics, it develops a causal loop diagram for proenvironmental behaviour (CLD‐PEB) that conceptualizes PEB as a dynamic system generated through interacting ...
Doyeon Ko, Sun‐Jin Yun, Tae‐Hoon Moon   +2 more
wiley   +1 more source

Substructural Fuzzy-Relevance Logic [PDF]

Notre Dame Journal of Formal Logic, 2015
This paper proposes a new topic in substructural logic for use in research joining the fields of relevance and fuzzy logics. For this, we consider old and new relevance principles. We first introduce fuzzy systems satisfying an old relevance principle, that is, Dunn’s weak relevance principle.
openaire   +2 more sources

Bi[IrBi6I12], Ag3[IrBi6I12], and BixCu3–3x[IrBi6I12]: Rock‐Salt Superstructures Based on Heavy‐Atom Clusters

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
New iridium‐containing bismuth subiodides based on cuboctahedral [IrBi6I12]3− clusters adopt chain‐like or rock‐salt‐related structure variants depending on the counter‐cations. Ag3[IrBi6I12] combines silver mobility at room temperature with long‐range ordering at low temperature, while DFT calculations reveal semiconducting behavior.
Noah Elsner, Vitaliy Romaka, Thomas Doert, Michael Ruck   +3 more
wiley   +1 more source

‘The Bethune College Sensation’: Gender, Archive and Radical Passivity

Gender &History, EarlyView.
ABSTRACT This article explores the student protests at Bethune College, Calcutta, on 3 February 1928, against the Simon Commission, a British parliamentary delegation that excluded Indian representation. On this day, female students staged a quiet but radical act of defiance by refusing to attend classes, sign apologies or vacate their hostel, despite ...
Meghmala Bhattacharya
wiley   +1 more source

Fitting in or Standing out? Women in Leadership in Pink Ghetto Industries in France

Gender, Work &Organization, EarlyView.
ABSTRACT Drawing on a combined theorization of gendered organizations, personal branding, and optimal distinctiveness theory (ODT), this study explores the experiences of women leaders in the French luxury industry, a context often associated with so‐called “pink ghetto” or feminized sectors.
Zuzanna Staniszewska, Géraldine Galindo, Tamer Koburtay   +2 more
wiley   +1 more source

Willingness to Donate to Racially Marked Non‐Governmental Organizations: The Case of Environmental Justice

Sociological Forum, EarlyView.
ABSTRACT Non‐governmental organizations (NGOs) rely on donor support to pursue their missions. As such, NGOs may forgo initiatives that do not appeal to constituents, such as racially coded activities. This dynamic is especially relevant for environmental NGOs (ENGOs), which have faced considerable pressure to integrate racial equity from environmental
Sam Castonguay, Dylan Bugden
wiley   +1 more source