Results 171 to 180 of about 40,678 (327)
Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease
Movement Disorders, EarlyView.ABSTRACT Background
Studies on brain connectivity offer important insights into the changes that occur in central network diseases such as Parkinson's disease (PD). Camptocormia, a condition characterized by abnormal flexion of the trunk, often occurs in advanced PD, but its underlying mechanisms are not yet clear.Tauqeer Anjum, Jan Raethjen, Hao Ding, Nabin Koirala, Rüdiger Pryss, Robin Wolke, Chi Wang Ip, Günther Deuschl, Jens Volkmann, Nils G. Margraf, Muthuraman Muthuraman +10 morewiley +1 more sourceReliability of Neuroimaging and Neurophysiological Tremor Features in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
Tremor is one of the cardinal motor symptoms of Parkinson's disease (PD). Its severity can be quantified with clinical rating scales and neurophysiology. The pathophysiology of PD tremor involves activity in the cerebello‐thalamo‐cortical circuit (CTC), which can be quantified with concurrent accelerometry‐functional magnetic ...Luca Angelini, Kevin van den Berg, Michiel Dirkx, Matteo Bologna, Bastiaan R. Bloem, Rick C.G. Helmich +5 morewiley +1 more sourceProbabilistic Mapping of Magnetic Resonance‐Guided Focused Ultrasound (MRgFUS) Thalamotomy Targets in Essential Tremor and Tremor‐Dominant Parkinson's Disease: Insights from a German Cohort
Movement Disorders, EarlyView.Precise targeting in magnetic resonance‐guided focused ultrasound (MRgFUS) is critical for effective tremor control in essential tremor and tremor‐dominant Parkinson's disease, as small deviations can reduce efficacy or cause side effects. In our cohort, sweetspots were identified at Montreal Neurological Institute (MNI) coordinates x = −12.4, y = −17 ...Jonas Krauss, Neeraj Upadhyay, Veronika Purrer, Valeri Borger, Marcel Daamen, Hannah Weiland, Angelika Maurer, Carsten Schmeel, Alexander Radbruch, Markus Essler, Ullrich Wüllner, Henning Boecker +11 morewiley +1 more sourceSurprises From the Basal Ganglia: Stop and Go Have New Meaning
Movement Disorders, EarlyView.Abstract
This perspective highlights new work suggesting the need for revision of the canonical direct–indirect model of the basal ganglia's influence on movement, with fresh evidence that there is a formerly unappreciated pair of direct and indirect pathways that parallel the standard model's canonical direct and indirect pathways, and promising ...Ann M. Graybielwiley +1 more sourceSomato‐Cognitive Action Network in Focal Dystonia
Movement Disorders, EarlyView.Abstract Background
The central pathology causing idiopathic focal dystonia remains unclear. The recently identified somato‐cognitive action network (SCAN) has been implicated. Objective
We tested whether the effector‐agnostic SCAN may constitute a central pathology shared across dystonia subtypes, whereas the effector‐specific regions in the primary ...Yuchao Wang, Baothy Huynh, Jianxun Ren, Mo Chen, Wei Zhang, Dan Hu, Shasha Li, Hesheng Liu, Teresa J. Kimberley +8 morewiley +1 more sourceBrain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy
Movement Disorders, EarlyView.Abstract Background
Clinical progression rate is the typical primary endpoint measure in progressive supranuclear palsy (PSP) clinical trials. Objectives
This longitudinal multicohort study investigated whether baseline clinical severity and regional brain atrophy could predict clinical progression in PSP–Richardson's syndrome (PSP‐RS).Andrea Quattrone, Nicolai Franzmeier, Hans‐Jürgen Huppertz, Nicholas Seneca, Gabor C. Petzold, Annika Spottke, Johannes Levin, Johannes Prudlo, Emrah Düzel, the PASSPORT Study Group, the AL‐108‐231 Investigators, the Arise Investigators, the Tauros MRI Investigators, the DESCRIBE‐PSP group, Ikuko Aiba, Angelo Antonini, Diana Apetauerova, Jean‐Philippe Azulay, Ernest Balaguer Martinez, Jee Bang, Paolo Barone, Matthew Barrett, Danny Bega, Daniela Berg, Koldo Berganzo Corrales, Yvette Bordelon, Adam L Boxer, Moritz Brandt, Norbert Brueggemann, Giovanni Castelnovo, Roberto Ceravolo, Rosalind Chuang, Sun Ju Chung, Alistair Church, Jean‐Christophe Corvol, Paola Cudia, Marian Dale, Luc Defebvre, Sophie Drapier, Erika D Driver‐Dunckley, Georg Ebersbach, Karla M Eggert, Aaron Ellenbogen, Alexandre Eusebio, Andrew H Evans, Natalia Fedorova, Elizabeth Finger, Alexandra Foubert‐Samier, Boyd Ghosh, Lawrence Golbe, Francisco Grandas Perez, Murray Grossman, Deborah Hall, Kyoko Hamada, Kazuko Hasegawa, Guenter Hoeglinger, Lawrence Honig, David Houghton, Xuemei Huang, Stuart Isaacson, Seong‐Beom Koh, Jaime Kulisevsky Bojarski, Anthony E. Lang, Peter Nigel Leigh, Irene Litvan, Juan Jose Lopez Lozano, Jose Luis Lopez‐Sendon Moreno, Albert Christian Ludolph, Ma Rosario Luquin Piudo, Irene Martinez Torres, Nikolaus McFarland, Wassilios Meissner, Tiago Mestre, Pablo Mir Rivera, Eric Molho, Britt Mollenhauer, Huw R Morris, Miho Murata, Tomokazu Obi, Fabienne Ory Magne, Padraig O'Suilleabhain, Rajesh Pahwa, Alexander Pantelyat, Nicola Pavese, Dmitry Pokhabov, Johannes Prudlo, Federico Rodriguez‐Porcel, James Rowe, Joseph Savitt, Alfons Schnitzler, Joerg B Schulz, Klaus Seppi, Binit Shah, Holly Shill, David Shprecher, Maria Stamelou, Malcolm Steiger, Yuji Takahashi, Hiroshi Takigawa, Carmela Tartaglia, Lars Toenges, Daniel Truong, Winona Tse, Paul Tuite, Dieter Volc, Anne‐Marie A Wills, Dirk Woitalla, Tao Xie, Tatsuhiko Yuasa, Sarah Elizabeth Zauber, Theresa Zesiewicz, David Williams, Anne Louise Lafontaine, Connie Marras, Mandar Jog, Michael Panisset, Anthony Lang, Lesley Parker, Alistair J. Stewart, Jean‐Christophe Corvol, Jean‐Philippe Azulay, Philippe Couratier, Brit Mollenhauer, Stefan Lorenzl, Albert Ludolph, Reiner Benecke, Günter Höglinger, Axel Lipp, Heinz Reichmann, Dirk Woitalla, Dennis Chan, Adam Zermansky, David Burn, Andrew Lees, Adam Boxer, Bruce L. Miller, Iryna V. Lobach, Erik Roberson, Lawrence Honig, Edward Zamrini, Rajesh Pahwa, Yvette Bor‐delon, Erika Driver‐Dunkley, Stephanie Lessig, Mark Lew, Kyle Womack, Brad Boeve, Joseph Ferrara, Argyle Hillis, Daniel Kaufer, Rajeev Kumar, Tao Xie, Steven Gunzler, Theresa Zesiewicz, Praveen Dayalu, Lawrence Golbe, Murray Grossman, Joseph Jancovic, Scott McGinnis, Anthony Santiago, Paul Tuite, Stuart Isaacson, Julie Leegwater‐Kim, Irene Litvan, Murray Grossman, David S. Knopman, Bruce L. Miller, Lon S. Schneider, Rachelle S. Doody, Lawrence I. Golbe, Erik D. Roberson, Mary Koestler, Clifford R. Jack, Viviana Van Deerlin, Christopher Randolph, Iryna V. Lobach, Illana Gozes, Steve Whitaker, Joe Hirman, Michael Gold, Bruce H. Morimoto, Anwar Ahmed, Ikuko Aiba, Alberto Albanese, Kelly Bertram, Yvette Bordelon, James Bower, Jared Brosch, Daniel Claassen, Carlo Colosimo, Jean‐Christophe Corvol, Paola Cudia, Antonio Daniele, Luc Defebvre, Erika Driver‐Dunckley, Antoine Duquette, Roberto Eleopra, Alexandre Eusebio, Victor Fung, David Geldmacher, Lawrence Golbe, Francisco Grandas, Deborah Hall, Taku Hatano, Günter U Höglinger, Lawrence Honig, Jennifer Hui, Diana Kerwin, Akio Kikuchi, Thomas Kimber, Takashi Kimura, Rajeev Kumar, Irene Litvan, Peter Ljubenkov, Stefan Lorenzl, Albert Ludolph, Zoltan Mari, Nikolaus McFarland, Wassilios Meissner, Pablo Mir Rivera, Hidek Mochizuki, John Morgan, Renato Munhoz, Noriko Nishikawa, John O'Sullivan, Tomoko Oeda, Hideki Oizumi, Osamu Onodera, Fabienne Ory‐Magne, Elizabeth Peckham, Ronald Postuma, Aldo Quattrone, Joseph Quinn, Stefano Ruggieri, Justyna Sarna, Paul E. Schulz, John Slevin, Michele Tagliati, Daryl Wile, Zbigniew Wszolek, Tao Xie, Theresa Zesiewicz, Juan C. Gómez, Beatriz Tijero, Rafael Villoria, Justo García de Yebenes, Jose L. Sendón, Eduardo Tolosa, Maria T. Buongiorno, Nuria Bargalló, Juan A. Burguera, Iñiguez Martinez, Javier Ruiz‐Martínez, Jorge Villanua, Francisco Vivancos, Isabel Ybot, Miquel Aguilar, Josep L. Dolz, Mercè Boada, Asuncion Lafuente, Miguel A. Tejero, Juan J. López‐Lozano, Marina Mata, Andreas Kupsch, Axel Lipp, Matthias Höllerhage, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Susanne Knake, Daniela Berg, Walter Maetzler, Karin K. Srulijes, Adriane Gröger, Albert Ludolph, Jan Kassubek, Malcom Steiger, Kevin Tyler, David J. Burn, Cristopher Morris, Andrew Lees, Helen Ling, Lisa Strycharczuk, Slawek Altenstein, Mathias Baehr, Miriam Barkhoff, Claudia Bartels, Bartl Michael, Rudi Beschorner, Eberhard Karls, Aline Beyle, Henning Boecker, Moritz Brandt, Kathrin Brockmann, Frederic Brosseron, Lena Burow, Cihan Catak, Arda Can Cetindag, Nicoleta Carmen Cosma, Marcel Daamen, Eman Dashti, Sylvia de Jonge, Peter Dechent, Martin Dichgans, Elisabeth Dinter, Laura Dobisch, Angelika Dörr, Markus Donix, Louisa Droste zu Senden, Alexander Drzezga, Emrah Düzel, Martin Dyrba, Marie Ehrlich, Matthias Endres, Tanja Engels, Ersin Ersözlü, Michael Ewers, Jennifer Faber, Björn Falkenburger, Frederike Fenski, Klaus Fließbach, Agnes Flöel, Silka Dawn Freiesleben, Franca Laura Fries, Ingo Frommann, Thomas Gasser, Wenzel Glanz, Doreen Goerss, Doreen Grieger‐Klose, Marcus Grobe‐Einsler, Martin Grond, Selim Üstün Gürsel, Annett Halle, Niels Hansen, Deike Hartmann, Lina Hassoun, Robert Haussmann, Julian Hellmann‐Regen, Guido Hennes, Wiebke Hermann, Andreas Hermann, Jochen Herms, Gabi Herrmann, Stefan Hetzer, Petra Hinderer, Günther U. Höglinger, Ildiko Horvath, Nicole Hujer, Enise Irem Incesoy, Alexander Jäck, Daniel Janowitz, Frank Jessen, Lorraine Jost, Pascal Kalbhen, Jan Kassubek, Sabrina Katzdobler, Ingo Kilimann, Okka Kimmich, Luca Kleinadam, Thomas Klockgether, Xenia Kobeleva, Patricia Krause, Elke Kuder‐Buletta, Andrea Kühn, Carolin Kurz, Catharina Lange, Chris Lappe, Christoph Laske, Johannes Levin, Sandra Lichte Schneider, Paul Lingor, Matthias Löhle, Albert C. Ludolph, Falk Lüsebrink, Cornelia McCormick, David Mengel, Coraline Metzger, Matthias Munk, Manuela Neumann, Demet Oender, Robert Perneczky, Oliver Peters, Gabor C. Petzold, Henrike Pfaff, Alexandra Polcher, Lukas Preis, Josef Priller, Johannes Prudlo, Dominik Pürner, Veronika Purrer, Boris Rauchmann, Alfredo Ramirez, Heike Raum, Sandra Röske, Christin Ruß, Petr Sabik, Yilmaz Sagik, Klaus Scheffler, Monika Schmidt, Anja Schneider, Luisa‐Sophie Schneider, Ludger Schoels, Björn Schott, Heike Schulz, Franziska Schulze, Sebastian Sodenkamp, Annika Spottke, Eike Spruth, Melina Stark, Matthis Synofzik, Patricia Sulzer, Stefan Teipel, Ina R Vogt, Michael Wagner, Endy Weidinger, Carlo Wilke, Jens Wiltfang, Steffen Wolfsgruber, Ullrich Wüllner, Renat Yakupov, Heike Zech, Inga Zerr, Gabriel Ziegler, Adelgunde Zollver, Günter U. Höglinger +424 morewiley +1 more sourceA Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective
Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...Mohammed Al‐Azzani, Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre, Michael Zech, Kevin Sicking, Alain Ibáñez de Opakua, Vidyashree Jayanthi, Leslie Amaral, Aishwarya Agarwal, Aswathy Chandran, Susana R. Chaves, Juliane Winkelmann, Claudia Trenkwalder, Maike Schwager, Silke Pauli, Ulf Dettmer, Claudio O. Fernández, Janin Lautenschläger, Markus Zweckstetter, Ruben Fernandez Busnadiego, Brit Mollenhauer, Tiago Fleming Outeiro +24 morewiley +1 more source
