Results 121 to 130 of about 561,652 (318)

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Number processing and arithmetic skills in children with cochlear implants

Frontiers in Psychology, 2014
Though previous findings report that hearing impaired children exhibit impaired language and arithmetic skills, our current understanding of how hearing and the associated language impairments may influence the development of arithmetic skills is still ...
Silvia ePixner, Martin eLeyrer, Korbinian eMoeller   +2 more
doaj   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)

FEBS Open Bio, EarlyView.
Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

A Novel mRNA Level Subtraction Method for Quick Identification of Target-Orientated Uniquely Expressed Genes Between Peanut Immature Pod and Leaf

Biological Procedures Online, 2010
Subtraction technique has been broadly applied for target gene discovery. However, most current protocols apply relative differential subtraction and result in great amount clone mixtures of unique and differentially expressed genes.
Wu Ning, Matand Kanyand, Williams Sonya
doaj  

Error analysis in fraction addition and subtraction using structured observed learning outcomes

African Journal of Teacher Education and Development
Background: Fractions are important because of their critical role in more advanced mathematics. While they are central to mathematics learning, they pose a challenge to learners.
Alphius Dube, Jeremiah S. Maseko
doaj   +1 more source

A Self-Consistent Subtraction Method in the Quantum Field Theory. II-1 [PDF]

, 1950
Hiroshi Fukuda, Yonezi Miyamoto, Sin‐itiro Tomonaga   +2 more
openalex   +1 more source

Pileup and underlying event mitigation with iterative constituent subtraction

Journal of High Energy Physics, 2019
The hard-scatter processes in hadronic collisions are often largely contaminated with soft background coming from pileup in proton-proton collisions, or underlying event in heavy-ion collisions. This paper presents a new background subtraction method for
P. Berta, L. Masetti, D.W. Miller, M. Spousta   +3 more
doaj   +1 more source

A Self-Consistent Subtraction Method in the Quantum Field Theory. II-2 [PDF]

, 1949
Hiroshi Fukuda, Y. Miyamoto, S.-i. Tomonaga   +2 more
openalex   +1 more source