Results 41 to 50 of about 43,210 (294)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Finding the thieves amongst the liars: Thinking clearly about cyber-enabled influence operations

European Journal of International Security
How do cyber attacks aid attempts to generate influence? This article argues that cyber-enabled influence operations (CEIO) are more varied in form than is often recognised by scholars.
Christopher Whyte, Ugochukwu Etudo
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

CONCLUSIONS ON HYBRID WARFARE [PDF]

Annals: Series on Military Sciences, 2019
A pioneer in the field of Public Relations, Edward L. Bernays, emphasized the use of words as weapons in his work entitled „Propaganda” in 1928. In „Public Relations”, he considered the word and image to be the representation of tools for building ...
Anghel ANDREESCU, Valentin DULGHERU
doaj  

Demystifying the past: mythical subversion in Herminio Martínez' novel Diario maldito de Nuño de Guzmán.

Amaltea: Revista de Mitocrítica, 2022
This article offers a myth-critical analysis of the novel Diario maldito de Nuño de Guzmán by Herminio Martínez, published in 1990. Firstly, arguments supporting the application of the term «myth» to the narrative of the Spanish Conquest of America ...
Edyta Andzel-O'Shanahan
doaj   +1 more source

Non‐Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA

Advanced Science, EarlyView.
The IgLec gene family generates both protein‐coding antiviral effectors and non‐coding transcripts. Upon viral infection, non‐coding transcripts are preferentially targeted by viral miR‐N48, thereby buffering protein‐coding isoforms from repression. Depletion of these decoy transcripts compromises antiviral defense, revealing a non‐coding RNA‐mediated ...
Ying Huang, Rui Shen, Xin Huang, Gu‐Qin Ji, Jiang‐Feng Lan, Qian Ren   +5 more
wiley   +1 more source

PERANGKAT LUNAK SUBVERSION PADA BASIS DATA MYSQL [PDF]

, 2009
Subversion merupakan salah satu perangkat lunak version control yang digunakan untuk manajemen pembangunan proyek perangkat lunak. Perangkat lunak ini mampu mencatat perubahan file, mengembalikan keadaan file ke titik tertentu, dan mampu menangani ...
Latif Bayutama
core  

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

True Grit et son héroïne, Mattie Ross : une voix pour les femmes ?

Babel: Littératures Plurielles, 2019
True Grit was published in the United States in 1968, at the height of the counterculture movement. This western was a bestseller although the founding values of America were being strongly challenged at the time.
Lucile Reynal de Saint Michel
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source