Advanced Science, EarlyView.This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł +8 more
wiley +1 more source
Retrospective empirical analysis of the success rate of inguinal hernia operations in outpatient and inpatient sectors: a cohort study. [PDF]
HerniaWiemschulte J, Messerle R, Schreyögg J.
europepmc +1 more source
Advanced Science, EarlyView.Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen +13 more
wiley +1 more source
Position paper on the existing selection procedure in Germany for the degree program human medicine - interim evaluation after four years. Position paper of the student selection (ASA) in the DACH Association for Medical Education (GMA). [PDF]
GMS J Med EducMüller-Hilke B, Gehlhar K.
europepmc +1 more source
Quantitative Stain Mapping in X‐Ray Virtual Histology
Advanced Science, EarlyView.Virtual histology promises 3D tissue examination without physical sectioning, yet has lacked the tissue‐specificity of conventional pathology. This work demonstrates the first quantitative three‐dimensional stain mapping at histologically relevant resolution, separating contrast agent from tissue to reveal cellular features such as nuclei. The approach
Dominik John +16 more
wiley +1 more source
Advanced Science, EarlyView.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Advanced Science, EarlyView.A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding +6 more
wiley +1 more source
Mid-Term Outcomes, Biological Responses and Complications of Dental Implants in Maxillomandibular Reconstruction with Free Bone Flaps: A Systematic Review and Meta-Analysis. [PDF]
Diagnostics (Basel)Qiu S, Hung KF, Wang F.
europepmc +1 more source
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Efficacy and safety of PreserFlo MicroShunt versus trabeculectomy in glaucoma patients: a systematic review, meta-analysis, and meta-regression of clinical outcomes and key covariates. [PDF]
BMC OphthalmolAl-Shammari YM +4 more
europepmc +1 more source