Interaction between the α-glucosidases, sucrase-isomaltase and maltase-glucoamylase, in human intestinal brush border membranes and its potential impact on disaccharide digestion [PDF]
Frontiers in Molecular Biosciences, 2023 The two major intestinal α-glycosidases, sucrase-isomaltase (SI) and maltase-glucoamylase (MGAM), are active towards α-1,4 glycosidic linkages that prevail in starch.
Stephanie Tannous +3 more
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Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels [PDF]
Biochemistry and Biophysics Reports, 2023 The Schlafen (Slfn) family proteins are critical regulators of cell proliferation, induction of immune responses, differentiation, self-restoration, and cell cycle progression.
Emilie E. Vomhof-DeKrey +3 more
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PLoS ONE, 2021 The intestinal epithelium requires self-renewal and differentiation in order to function and adapt to pathological diseases such as inflammatory bowel disease, short gut syndrome, and ulcers. The rodent Slfn3 protein and the human Slfn12 analog are known
Emilie E. Vomhof-DeKrey +4 more
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Sucrase Is an Intramolecular Chaperone Located at the C-terminal End of the Sucrase-Isomaltase Enzyme Complex [PDF]
Journal of Biological Chemistry, 2002 The sucrase-isomaltase enzyme complex (pro-SI) is a type II integral membrane glycoprotein of the intestinal brush border membrane. Its synthesis commences with the isomaltase (IM) subunit and ends with sucrase (SUC). Both domains reveal striking structural similarities, suggesting a pseudo-dimeric assembly of a correctly folded and an enzymatically ...
Ralf, Jacob +2 more
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BMC Gastroenterology, 2020 Background Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum.
Paul Wasuwanich +8 more
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Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration. [PDF]
PLoS ONE, 2013 Significant advances in intestinal stem cell biology have been made in murine models; however, anatomical and physiological differences between mice and humans limit mice as a translational model for stem cell based research.
Liara M Gonzalez +4 more
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Review: Nutritional regulation of intestinal starch and protein assimilation in ruminants
Animal, 2020 Pregastric fermentation along with production practices that are dependent on high-energy diets means ruminants rely heavily on starch and protein assimilation for a substantial portion of their nutrient needs. While the majority of dietary starch may be
D.L. Harmon, K.C. Swanson
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Dissociation of Small‐Intestinal Sucrase. Isomaltase Complex into Enzymatically Active Subunits [PDF]
European Journal of Biochemistry, 1975 1. The sucrase - isomaltase complex from rabbit small intestine dissociated into its subunits upon reaction with citraconic anhydride. They can recombine after deacylation under mild acidic conditions. 2. When citraconylated, the subunits could be separated and isolated in a catalytically active form. 3. The previously reported procedure for separation
H, Braun, A, Cogoli, G, Semenza
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Demonstration of sucrase-isomaltase complex in chick intestine.
Journal of Nutritional Science and Vitaminology, 1982 It was investigated whether sucrase and isomaltase form an enzyme-enzyme complex in chick intestine or not, and some properties of the disaccharidases were compared with those of other species. 1) Chick intestinal sucrase and isomaltase were shown to exist in the form of an enzyme-enzyme complex from the results of polyacrylamide disc gel ...
K, Mizuno, S, Moriuchi, N, Hosoya
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Does sucrase—isomaltase always exist as a complex in human intestine?
FEBS Letters, 1979 The sucrase-isomaltase of the small intestinal brush border membrane has been isolated as a complex from a number of species [l-3]. In addition studies on human small intestine suggested the presence of free sucrase [4-61 and isomaltase [ 5,6]. However, papain treatment or autolysis used in these studies to release the enzymes may have induced changes ...
Skovbjerg, Hanne +2 more
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