Results 21 to 30 of about 1,571 (110)

Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex. [PDF]

The EMBO Journal, 1988
Lysosomal alpha-glucosidase (acid maltase) is essential for degradation of glycogen in lysosomes. Enzyme deficiency results in glycogenosis type II. The amino acid sequence of the entire enzyme was derived from the nucleotide sequence of cloned cDNA.
L H, Hoefsloot, M, Hoogeveen-Westerveld, M A, Kroos, J, van Beeumen, A J, Reuser, B A, Oostra   +5 more
openaire   +2 more sources

Schlafen 3 knockout mice display gender-specific differences in weight gain, food efficiency, and expression of markers of intestinal epithelial differentiation, metabolism, and immune cell function.

PLoS ONE, 2019
Self-renewal and differentiation are essential for intestinal epithelium absorptive functioning and adaptation to pathological states such as short gut syndrome, ulcers, and inflammatory bowel disease.
Emilie E Vomhof-DeKrey, Jun Lee, Jack Lansing, Chris Brown, Diane Darland, Marc D Basson   +5 more
doaj   +1 more source

Developmental changes in the sucrase-isomaltase complex in rat intestinal mucosa.

Journal of Nutritional Science and Vitaminology, 1978
Developmental changes in sucaras-isomaltase complex formation were investigated in intestinal mucosal homogenates and brush border membranes of 15-day-old, 18-day-old and adult rats using Sephadex G-200 column chromatography and polyacrylamide disc gel electrophoresis. Disaccharidases were solubilized by papain treatment.
K, Yamada, S, Moriuchi, N, Hosoya
openaire   +3 more sources

Impaired digestive function of sucrase-isomaltase in a complex with the Greenlandic sucrase-isomaltase variant

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Sucrase isomaltase (SI) is the most prominent disaccharidase in the small intestine. Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A homozygous frameshift mutation, c.273_274delAG (p.Gly92Leufs*8), has been identified in CSID in the Greenlandic population.
Stephanie, Tannous, Hassan Y, Naim
openaire   +2 more sources

Effects of Hydrocortisone on the Formation of Sucrase-Isomaltase Complex

Eiyo To Shokuryo, 1978
授乳期の白ネズミにおいて, 小腸粘膜の二糖類水解酵素のヒドロコーチゾンによる誘導を観察し, スクラーゼ・イソマルターゼ複合体の形成を比較検討した。1) ヒドロコーチゾンは生後15日の白ネズミ小腸のスクラーゼ, イソマルターゼ活性を約20倍前後に増大し, マルターゼ活性を約3倍に増大した。2) スクラーゼとイソマルターゼは最初から複合体としては存在しておらず, ヒドロコーチゾンによって, 複合体形成は促進されるとともに, 複合体のスクラーゼ/イソマルターゼの活性比は増大した。
Kazuhiko YAMADA, Sachiko MORIUCHI, Norimasa HOSOYA   +2 more
openaire   +2 more sources

Affinity Labeling of the Active Sites in the Sucrase-Isomaltase Complex from Small Intestine

Journal of Biological Chemistry, 1974
Abstract Conduritol-B-epoxide, a compound structurally related to the substrates of sucrase and isomaltase is an active-site-directed inhibitor. The inactivation of sucrase and isomaltase can be complete, is irreversible, and is prevented by the presence of reversible competitive inhibitors and substrates. During the inactivation 1 mole of inhibitor is
A, Quaroni, E, Gershon, G, Semenza
openaire   +2 more sources

Suppressive effect of insulin on the synthesis of sucrase–isomaltase complex in small intestinal epithelial cells, and abnormal increase in the complex under diabetic conditions [PDF]

Biochemical Journal, 1998
An abnormally high level of the sucrase-isomaltase (SI) complex in the small intestine of rats with streptozotocin-induced insulin-dependent diabetes mellitus (IDDM) was normalized in 11 h by the administration of insulin, in addition to normalization of the blood glucose level.
M, Takenoshita, R, Yamaji, H, Inui, K, Miyatake, Y, Nakano   +4 more
openaire   +2 more sources

Some properties of luminal sucrase and sucrase-isomaltase complex in rat small intestine.

Journal of Nutritional Science and Vitaminology, 1985
Some properties of luminal sucrase-isomaltase complex and the effect of luminal fluid on their complex were studied in rat small intestine. Luminal contents were collected by flushing the small intestine with the buffered solution. The enzyme activity was observed in luminal contents and intestinal mucosa. Sucrase and isomaltase activities were located
M, Abe, K, Yamada, N, Hosoya, S, Moriuchi   +3 more
openaire   +3 more sources

15. ON THE PRIMARY SITE OF CONTROL IN SPONTANEOUS AND IN GLUCOCORTICOID-TRIGGERED PRECOCIOUS DEVELOPMENT OF SMALL-INTESTINAL SUCRASE-ISOMALTASE COMPLEX [PDF]

Pediatric Research, 1987
15. ON THE PRIMARY SITE OF CONTROL IN SPONTANEOUS AND IN GLUCOCORTICOID-TRIGGERED PRECOCIOUS DEVELOPMENT OF SMALL-INTESTINAL SUCRASE-ISOMALTASE ...
G Sebastio, W Hunziker, A Ballabio, L Maiuri, S Auricchio, G Semenza   +5 more
openaire   +1 more source

Investigation of the Mechanism of Shen‐Ling‐Bai‐Zhu‐San Polysaccharide in Counteracting Lactose Intolerance Diarrhea Via Network Pharmacology, Molecular Docking, and Experimental Validation

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Background Lactose intolerance (LI)‐related diarrhea is a prevalent clinical gastrointestinal condition that severely compromises patients’ quality of life. While the traditional Chinese medicine formula Shen‐Ling‐Bai‐Zhu‐San (SL) has proven effective in managing this disorder, whether polysaccharides derived from SL (SLP) produce comparable ...
Chunfeng Mei, Lili Han, Mengxiong Lu, Hong Xue, Xiaolong Ji   +4 more
wiley   +1 more source