Results 111 to 120 of about 23,186 (272)

Unique features of seizure‐induced cardiorespiratory failure in SSKcnj16−/− rats: Implications for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure‐induced disruption of vital physiological systems. The objective of this study was to characterize seizure‐induced physiological dysfunction leading to death in SSKcnj16−/− rats and ...
Melissa Eilbes, Alexander Gallo, Wasif A. Osmani, Paloma Bittencourt‐Silva, Anna D. Manis, Matthew R. Hodges   +5 more
wiley   +1 more source

Are Variants Causing Cardiac Arrhythmia Risk Factors in Sudden Unexpected Death in Epilepsy?

Frontiers in Neurology, 2020
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute and adaptive changes in heart rhythm in epilepsy implicate cardiac dysfunction as a potential pathogenic mechanism in SUDEP ...
Lauren E. Bleakley, Ming S. Soh, Richard D. Bagnall, Richard D. Bagnall, Lynette G. Sadleir, Samuel Gooley, Christopher Semsarian, Christopher Semsarian, Ingrid E. Scheffer, Ingrid E. Scheffer, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid   +12 more
doaj   +1 more source

Altered brain connectivity in sudden unexpected death in epilepsy (SUDEP) revealed using resting-state fMRI. [PDF]

, 2019
The circumstances surrounding SUDEP suggest autonomic or respiratory collapse, implying central failure of regulation or recovery. Characterisation of the communication among brain areas mediating such processes may shed light on mechanisms and ...
B, Diehl, Ca, Scott, Ja, Ogren, L, Lemieux, LA, Allen, M, Guye, R, Kumar, Rm, Harper, S, Ourselin, Sb, Vos, Sd, Lhatoo   +10 more
core  

Baseline elevation and reduction in cardiac electrical instability assessed by quantitative T-wave alternans in patients with drug-resistant epilepsy treated with vagus nerve stimulation in the AspireSR E-36 trial [PDF]

, 2016
Objective: Reports of cardiac arrhythmias and cardiac pathology at postmortem examination of patients with epilepsy suggest a possible cardiac component of risk for sudden unexpected death in epilepsy (SUDEP).
Boon, Paul, Nearing, Bruce D, Olin, Bryan, Schachter, Steven C, Verrier, Richard L   +4 more
core   +2 more sources

Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases

Epilepsia, EarlyView.
Abstract Objective We retrospectively investigated a cohort of patients with ring chromosome 20 syndrome (r20), aiming to provide information on the prognosis of r20 regarding seizures, cognitive function, comorbidities, and social living. Methods Patients diagnosed with r20 in our hospital were identified, and clinical data were extracted from medical
Kentaro Tokumoto, Takuji Nishida, Hitoshi Ikeda, Hiroko Ikeda, Norihiko Kawaguchi, Satoshi Mizutani, Tokito Yamaguchi, Hideyuki Ohtani, Etsuko Yamazaki, Naotaka Usui, Katsumi Imai, Yushi Inoue   +11 more
wiley   +1 more source

Heart rate variability during epileptic seizures as a factor in the development of sudden unexpected death in epilepsy (literature review)

Русский журнал детской неврологии, 2019
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with epilepsy and occurs at least 20 times more often in patients with fore mentioned condition compared with healthy people.
A. V. Monakhova, A. Yu. Yakshina, E. D. Belousova   +2 more
doaj   +1 more source

A Sudden Unexpected Death in Epilepsy [PDF]

, 2007
Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, non-traumatic, and non-drowning death in epilepsy. Postmortem examination must not reveal any anatomical or toxicological causes for SUDEP.
김원주, 최영철
core  

Cardiac investigations in sudden unexpected death in DEPDC5-related epilepsy [PDF]

, 2022
Objective: Germline loss-of-function mutations in DEPDC5, and in its binding partners (NPRL2/3) of the mammalian target of rapamycin (mTOR) repressor GATOR1 complex, cause focal epilepsies and increase the risk of sudden unexpected death in epilepsy ...
Adle-Biassette, H, An, I, Bacq, A, Baulac, S, Bonduelle, T, Genomics UK Research Consortium, ., Jennesson, M, Maletic, M, Marchal, C, Navarro, V, Picard, F, Ribierre, T, Roussel, D, Sisodiya, SM, Zagaglia, S   +14 more
core  

Reduction of generalized tonic–clonic seizures following vagus nerve stimulation therapy: CORE‐VNS Study 24‐month follow‐up

Epilepsia, EarlyView.
Abstract Objective Generalized tonic–clonic seizures (GTCS) are considered to be among the most devastating seizures due to increased health risks. Use of device‐based therapies, such as vagus nerve stimulation (VNS), is common for those resistant to antiseizure medications and important for those in whom resective surgery is not feasible.
Ana Suller Marti, Ryan Verner, Mark Keezer, Andrea Andrade, Martin Veilleux, Kenneth Myers, Gaia Giannicola, Kathryn Nichol, Jorge G. Burneo, on behalf of the CORE‐VNS Registry Group   +9 more
wiley   +1 more source

Deep brain stimulation of the centromedian nucleus for drug‐resistant epilepsy in children: Quality‐of‐life and functional outcomes from the CHILD‐DBS registry

Epilepsia, EarlyView.
Abstract Objective Deep brain stimulation of the centromedian nucleus of the thalamus (CM‐DBS) is an investigational, off‐label treatment for drug‐resistant epilepsy (DRE) in children. Although emerging evidence supports its safety and efficacy for select indications, the effect of CM‐DBS on quality of life and functional outcomes such as school ...
Karim Mithani, Farbod Niazi, Hrishikesh Suresh, Yousof Alrumayyan, Eriberto R. Rayco, Ayako Ochi, Hiroshi Otsubo, Elizabeth Kerr, Sara Breitbart, Andrea LeBlanc‐Millar, Nisha Gadgil, Jeffrey S. Raskin, Alexander G. Weil, Aristides Hadjinicolaou, Christian Iorio‐Morin, Shelly Weiss, Puneet Jain, Lauren Sham, Elizabeth Donner, Alfonso Fasano, Carolina Gorodetsky, George M. Ibrahim   +21 more
wiley   +1 more source