Risk of sudden unexpected death in epilepsy (SUDEP) with lamotrigine and other sodium channel-modulating antiseizure medications. [PDF]
Epilepsia Open, 2023 In vitro data prompted U.S Food and Drug Administration warnings that lamotrigine, a common sodium channel modulating anti‐seizure medication (NaM‐ASM), could increase the risk of sudden death in patients with structural or ischaemic cardiac disease ...
Nightscales R +14 more
europepmc +2 more sources
Epilepsy professionals' views on sudden unexpected death in epilepsy counselling: A tale of two countries. [PDF]
Eur J NeurolSudden unexpected death in epilepsy (SUDEP) is a leading cause of epilepsy mortality. All international guidance strongly advocates for clinicians working with people with epilepsy (PWE) to discuss SUDEP.
Watkins L +5 more
europepmc +2 more sources
Electroencephalography characteristics related to risk of sudden unexpected death in epilepsy in patients with Dravet syndrome. [PDF]
Front Neurol, 2023 Objective To investigate the quantitative electroencephalography (EEG) features associated with a high risk of sudden unexpected death in epilepsy (SUDEP) in patients with Dravet syndrome (DS).
Kim JY, Shin J, Kim L, Kim SH.
europepmc +2 more sources
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy. [PDF]
Brain Commun, 2023 Voltage-gated sodium channel β1 subunits are essential proteins that regulate excitability. They modulate sodium and potassium currents, function as cell adhesion molecules and regulate gene transcription following regulated intramembrane proteolysis ...
Chen C +16 more
europepmc +2 more sources
Sudden unexpected death in epilepsy in children
Developmental Medicine & Child Neurology, 2023 AbstractSudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy‐related mortality in children and adults living with epilepsy. The incidence of SUDEP is comparable in both children and adults; it is approximately 1.2 per 1000 person years.
Robyn Whitney +2 more
openaire +3 more sources
Genetic Basis of Sudden Unexpected Death in Epilepsy [PDF]
Frontiers in Neurology, 2017 People with epilepsy are at heightened risk of sudden death compared to the general population. The leading cause of epilepsy-related premature mortality is sudden unexpected death in epilepsy (SUDEP).
Richard D. Bagnall +6 more
doaj +5 more sources
Sudden, unexpected death in epilepsy in children [PDF]
Seizure, 1997 Sudden, unexpected death in epilepsy (SUDEP) remains a controversial and enigmatic syndrome, particularly in children where the incidence, prevalence and risk factors may, and probably do, differ from adults. This study demonstrates (and further reinforces) the difficulties and inability of retrospective and coroner/death certificate-derived data in ...
Appleton, R.E.
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Heart rate variability modification as a predictive factor of sudden unexpected death in epilepsy: How far are we? A systematic review and meta‐analysis [PDF]
European Journal of Neurology, 2023 Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected death in people with epilepsy, with or without evidence of an epileptic seizure.
Giacomo Evangelista +9 more
openalex +2 more sources
Diaphragmatic pacing for the prevention of sudden unexpected death in epilepsy. [PDF]
Brain Commun, 2022 Sudden unexpected death in epilepsy is the leading cause of epilepsy related death. Currently, there are no reliable methods for preventing sudden unexpected death in epilepsy. The precise pathophysiology of sudden unexpected death in epilepsy is unclear;
Purnell BS +4 more
europepmc +2 more sources
The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy [PDF]
Frontiers in Neuroscience, 2021 Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive excitation.
Benton S. Purnell +3 more
openalex +2 more sources