Results 91 to 100 of about 5,336 (204)

Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP) [PDF]

, 2016
La SUDEP (Sudden Unexpected Death in Epilepsy) è una complicanza devastante dell’epilessia e rappresenta la più comune causa di mortalità prematura in epilessia.
Balestrini, Simona
core  

ECG in epilepsy – Insights on preemptive sudden death detection

Epilepsia, EarlyView.
Guilherme L. Fialho, Katia Lin
wiley   +1 more source

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Orrin Devinsky, Antonio Gil‐Nagel, Renzo Guerrini, Kelly G. Knupp, M. Scott Perry, Rocío Sánchez‐Carpintero, An‐Sofie Schoonjans, Ingrid E. Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine C. Wirrell, Diego Morita, Patrick Healy, Mélanie Langlois, Amélie Lothe, Lieven Lagae   +20 more
wiley   +1 more source

Efficacy of stiripentol, fenfluramine, and their combination on clinical outcomes in Dravet syndrome: A preliminary report

Epilepsia Open, EarlyView.
Abstract Objective Stiripentol and fenfluramine are approved treatments for Dravet syndrome (DS), but real‐world data comparing their effectiveness and combined use remain limited. Our study aims to explore associations between treatment with stiripentol, fenfluramine, and their combination and clinical outcomes in patients with DS.
Paolo Surdi, Marina Trivisano, Mattia Mercier, Nicola Pietrafusa, Angela De Dominicis, Costanza Calabrese, Simona Cappelletti, Nicola Specchio   +7 more
wiley   +1 more source

Enhancing sudden unexpected death in epilepsy (SUDEP) research through development of common data elements

Epilepsia Open
Objective Sudden Unexpected Death in Epilepsy (SUDEP) is a fatal complication for individuals living with epilepsy and is associated with significant personal and public burden.
Sloka S. Iyengar, Elaine K. O'Loughlin, Lauren Harte‐Hargrove, Mary Holmay, Laura S. Lubbers, CURE Epilepsy SUDEP Data Standardization Project Steering Committee, CURE Epilepsy SUDEP Data Standardization Project Working Group Members   +6 more
doaj   +1 more source

Fenfluramine in Rett syndrome: A multidimensional clinical study

Epilepsia Open, EarlyView.
Abstract Objective Rett syndrome (RTT) is a severe neurodevelopmental disorder frequently associated with drug‐resistant epilepsy, autonomic dysfunction, respiratory abnormalities, sleep disturbances, and behavioral impairment. Fenfluramine has shown efficacy in developmental and epileptic encephalopathies and may provide broader therapeutic benefits ...
Elena Gonzalez‐Alguacil, Nuria Lamagrande Casanova, Manuel Luján Bonete, David Mansilla Lozano, Juan José García Peñas, María Ballará Petitbó, Rocío Trincado Lamuño, Verónica Cantarín‐Extremera, Raquel Díaz Conejo, César Rodríguez Sánchez, Adrián García Ron, Víctor Soto Insuga   +11 more
wiley   +1 more source

Implications of Death Certification on Sudden Unexpected Death in Epilepsy (SUDEP) Research

, 2016
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in individuals with chronic, uncontrolled epilepsy. Epidemiologists use information on death certificates to study SUDEP. Certification of seizure-related deaths varies.
Daniel S. Atherton, Dale C. Hesdorffer, Cyndi Wright, Gregory G. Davis, Orrin Devinsky   +4 more
core   +1 more source

Wavelet phase coherence of ictal scalp EEG-extracted muscle activity (SMA) as a biomarker for sudden unexpected death in epilepsy (SUDEP).

PLoS ONE
ObjectiveApproximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP).
Adam C Gravitis, Krishram Sivendiran, Uilki Tufa, Katherine Zukotynski, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L Carlen, Berj L Bardakjian   +8 more
doaj   +1 more source

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2166-2171, October 2026.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

Near-SUDEP Event in Patient 2

, 2018
Near-SUDEP Event in Patient
Reick-Mitrisin, Victoria, Lhatoo, Samden D., Ogren, Jennifer, Maromi Nei (6161135), Kingman Strohl (6161138), Nei, Maromi, Hupp, Norma J., Sanju, Rup K., Catherine Scott (502007), Richerson, George B., Strohl, Kingman, Laura Vilella (6161120), Schuele, Stephan, Daniel Friedman (3324960), Rani, M. R. Sandhya, Zaremba, Anita, Diehl, Beate, Ryvlin, Philippe, Scott, Catherine, Jennifer Ogren (3939674), Orrin Devinsky (356636), Brian K. Gehlbach (6161141), Nassim Shafiabadi (6161153), Johnson P. Hampson (6161126), Ronald M. Harper (8035574), Beate Diehl (6161162), Devinsky, Orrin, Norma J. Hupp (6161147), Samden D. Lhatoo (6161171), Zhao, Xihue, Harper, Ronald M., Bilal Zony (6161144), Rup K. Sanju (6161132), George B. Richerson (6161168), Lacuey, Nuria, Victoria Reick-Mitrisin (1532176), Friedman, Daniel, M. R. Sandhya Rani (8035580), Vilella, Laura, Lisa Bateman (6161165), Anita Zaremba (6161150), Shafiabadi, Nassim, Zony, Bilal, Nuria Lacuey (6161123), Stephan Schuele (6161159), Bateman, Lisa, Hampson, Johnson P., Gehlbach, Brian K., Xihue Zhao (6161156), Philippe Ryvlin (95225)   +49 more
core   +1 more source