Results 31 to 40 of about 2,404,149 (283)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case series

Cephalalgia Reports
Background Cluster headache is an excruciating condition for which standard treatments are usually insufficient. Evidence has accumulated that serotonergic psychedelic indoleamines including psilocybin and LSD can be effective in preventing attacks ...
Jonathan Leighton, Carmen Lau, Aisha Savdo, Livia Granata   +3 more
doaj   +1 more source

The Conjecture of Sovereignty: New Anxieties for the Subject

Journal of Extreme Anthropology, 2018
Sovereignty continues to be an issue for political theorisation of its adherence to and resistance against specific ideological forms and interventions. Many of these political deliberations have assumed the constitution and contours of sovereignty to be
Cindy Lee Zeiher
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Nudity as Punishment: Problems of Physicality in the Penitentiary Sphere

Corpus Mundi
The article examines the problems of combining various types of punishment and nudity from a historical perspective. The study is based on a combination of historical-genetic and comparative methods, designed to collectively compare the specific features
Maxim V. Pulkin
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Quality of life and satisfaction with services in caregivers of children with cancer

نشریه پرستاری ایران, 2011
Background & Aim: Quality of life has been defined in a variety of ways depending on the context and the orientation of scholars. The purpose of the this study was to evaluate caregivers ' quality of life and also to investigate the correlation between ...
Sajjadi H, Roshanfekr P, Asangari B, Zeinali Maraghe M, Gharai N, Torabi F   +5 more
doaj  

Pandemic Disruptions of Older Adults’ Meaningful Connections: Linking Spirituality and Religion to Suffering and Resilience

Religions, 2022
The COVID-19 pandemic has upended the lives of persons of all ages throughout the world. Older adults have been particularly susceptible to the virus and have died at higher rates than any other age group.
Susan H. McFadden
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source