Results 201 to 210 of about 1,857,722 (261)

Functional stability assessment and adaptation for critical infrastructure facilities. [PDF]

Front Artif Intell
Perederyi V, Borchik E, Zosimov V, Bulgakova O.   +3 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Development of an Instrumented Climbing Hold with an Embedded Six-Axis Force Sensor for Speed Climbing. [PDF]

Sensors (Basel)
Kawamura A, Shintani T, Aihara S, Kurazume R.   +3 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

"At Least the Second Plate": rethinking nutritional care in the geriatric unit. [PDF]

J Nutr Health Aging
Marzetti E, Calvani R, Coelho-Junior HJ.
europepmc   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

The role of physical activity in self-rated health in a region affected by mining dam collapse: Brumadinho Health Project. [PDF]

Front Public Health
Peixoto SV, Nascimento-Souza MA, Mambrini JVM, Firmo JOA, Lima-Costa MF.   +4 more
europepmc   +1 more source

Redefining Antimicrobial Resistance in <i>Acinetobacter baumannii</i>: A Mechanistic Framework Linking Intracellular Antibiotic Activity to Treatment Failure. [PDF]

Int J Mol Sci
Elbehiry A, Abalkhail A, Alotaibi SA, Marzouk E.   +3 more
europepmc   +1 more source

The chloroplast cysteine synthase complex in guard cells is critical for stress-induced stomatal closure. [PDF]

Plant Physiol
Sun SK, Hell R, Wirtz M.
europepmc   +1 more source