Results 131 to 140 of about 846,250 (270)
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Ultrahigh-dimensional sufficient dimension reduction for censored data with measurement error in covariates. [PDF]
J Appl Stat, 2022 Chen LP.
europepmc +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Distance-Based Independence Screening for Canonical Analysis
, 2019 This paper introduces a new method named Distance-based Independence Screening for Canonical Analysis (DISCA) to reduce dimensions of two random vectors with arbitrary dimensions.
Huo, Xiaoming, Yu, Chuanping
core
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Neural Networks Perform Sufficient Dimension Reduction
Proceedings of the AAAI Conference on Artificial IntelligenceThis paper investigates the connection between neural networks and sufficient dimension reduction (SDR), demonstrating that neural networks inherently perform SDR in regression tasks under appropriate rank regularizations. Specifically, the weights in the first layer span the central mean subspace. We establish the statistical consistency of the neural
Xu, Shuntuo, Yu, Zhou
openaire +2 more sources
Nonlinear dimension reduction for regression with nearest neighbors
, 2013 Let $(X,Y)$ be an $\mathcal X\times\mathbb R$ valued random variable, where $\mathcal X\subset \mathbb R^p$. We generalize to a nonlinear framework the sufficient dimension reduction approach, followed by Cadre and Dong (2010), for estimating the ...
Paris, Quentin
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Review of sparse sufficient dimension reduction: comment
Statistical Theory and Related Fields, 2020 Liping Zhu
doaj +1 more source