Results 111 to 120 of about 1,200,087 (341)
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez+3 more
wiley +1 more source
Durkheim argued that strong social relationships protect individuals from suicide. We posit, however, that strong social relationships also have the potential to increase individuals’ vulnerability when they expose people to suicidality.
Seth Abrutyn, Anna S. Mueller
semanticscholar +1 more source
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring+6 more
wiley +1 more source
Effects of deep brain stimulation and verbal suggestions on pain in Parkinson’s disease
In Parkinson’s disease (PD) patients, verbal suggestions have been shown to modulate motor and clinical outcomes in treatment with subthalamic deep brain stimulation (DBS). Furthermore, DBS may alleviate pain in PD.
Rosenkjær Sophie+6 more
doaj +1 more source
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke+2 more
wiley +1 more source
Historical “gothic” novel in the context of English preromantic literature
The article discusses the development of the Gothic historical novel in English literature of the last third of the XVIII century. Initial installation on a stylized medieval romance, and attempts to reconstruct historical color associated with the ...
Grigorieva Elena Valentinovna
doaj
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek+15 more
wiley +1 more source
The aim of this paper is to shed light on two lesser-known aspects of Adorno’s work on philosophy: “mental reservations”, and the ability to “resist suggestion”.
Aurélia Peyrical
doaj +1 more source