Results 111 to 120 of about 544,105 (249)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 2013 This thesis deals with the automatic keywords suggestion. The suggestion is based only on the statistic methods. For the analysis are used diploma thesis and similar documents. Statistic methods are detailed tested and evaluated by using these documents.
Šimara, Svatopluk
core
Study on the Way to Manage Mini-watershed in Community Forestry
Shuitu baochi yanjiu, 2010 Community forestry is thought as the operations taking development of rural economy as the main purpose,and improving the rural ecological environment and living conditions of farmers and forestry.
SONG Zi-gang1, LI Zhong-kui2
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Suggestion Schemes and Communication
, 2003 It is not unusual for a computer based information system to serve more than one purpose. A computer supported suggestion scheme, though designed to promote and control the flow and evaluation of ideas for organisational improvement, may al so provide an
Helbling, Cornelia +2 more
core
Shuitu baochi yanjiu, 2006 According to the study on the shape and structural characteristics of a landslide,the condition and mechanism of origin cause of formation are analyzed.On the basis of the analysis of its mechanism causes,through the transitions of the coefficient law ...
WANG Xiang-feng +2 more
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source