Results 291 to 300 of about 1,200,087 (341)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability. [PDF]

Elife
Tsukada K, Imamura R, Miyake T, Saikawa K, Saito M, Kase N, Fu L, Ishiai M, Matsumoto Y, Shimada M.   +9 more
europepmc   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

Response to the comment on "Diagnostic value of a computer-assisted diagnosis system for the ultrasound features in thyroid nodules". [PDF]

Arch Endocrinol Metab
Wang Y.
europepmc   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Prevalence and associated factors of microbial water quality from drinking water in Ethiopia: A systematic review and meta-analysis protocol. [PDF]

PLoS One
Worku AD, Alemu BM.
europepmc   +1 more source

Correction: Acceptability and feasibility of HIV self-testing among transgender people in Larkana, Pakistan: Results from a pilot project. [PDF]

PLoS One
Altaf A, Pasha MSK, Majeed A, Ali W, Alaama AS, Jamil MS.   +5 more
europepmc   +1 more source

On the scarcity of home grown fruits in Great Britain with remedial suggestions ...

Charles Roach Smith
openalex   +2 more sources

Key factors in supporting adolescents to achieve high self-esteem and a positive body image: A qualitative community-based study. [PDF]

PLoS One
Artigues-Barberà E, Tort-Nasarre G, Pollina-Pocallet M, Ferrer Suquet Y, Ayats Pallés A, Guasch Niubó O, Ortega-Bravo M, García-Martínez E.   +7 more
europepmc   +1 more source

Response to Letter to the Editor on "The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study". [PDF]

Sex Med
Peng J, An J, Chen Y, Zhou J, Xiang B.
europepmc   +1 more source