Results 81 to 90 of about 442,669 (291)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Pain distribution: violence in public and private life in the 18th – early 20th centuries (on materials of Olonets province)

open access: yesStudia Humanitatis, 2016
The article describes the basic trends of social and status changes occurring under the influence of the process referred to as “pain distribution”. Traditional culture included a number of constraints designed to reduce aggressive tendencies in the ...
Pulkin Maxim Viktorovich
doaj  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Automatic Control Model of an Offshore Crane

open access: yesShiyou jixie, 2017
To promote the process of serialization,automation and informatization of offshore platform crane products,the technical status of marine crane control system has been analyzed and an iCrane control system model has been presented.The model composition ...
Liu Qimeng   +5 more
doaj  

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

On the methods of multimodal suggestive psychotherapy

open access: yesПроблеми сучасної психології, 2017
Some methodological aspects of multimodal suggestive psychotherapy are investigated. It is established that multimodal suggestive psychotherapy is an original psychotherapeutic system with its specific theoretical base and methodological principles. It
I. F. Manilov
doaj  

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