Results 51 to 60 of about 170,148 (277)
Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects
Advanced Science, EarlyView.The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su +14 more
wiley +1 more source
The Rhetoric of Neutrality and the Philosophers’ Brief: A Critique of the Amicus Brief of Six Moral Philosophers in Washington v. Glucksberg and Vacco v. Quill [PDF]
, 1998 Church discusses the amicus brief to the US Supreme Court in the companion assisted suicide cases of Washington v. Glucksberg and Vacco v. Quill, in which six philosophers offer their views.
Church, Richard
core +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Escape from New York: Analyzing the State\u27s Relative Interests in Proscribing the Withdrawal of Life Support and Physician-Assisted Suicide [PDF]
, 2003 This Note argues that states cannot consistently prohibit physician assisted suicide for terminally ill patients while they continue to allow the withdrawal of life support for even non-terminal patients.
Miller, Colin
core +2 more sources
Advanced Science, EarlyView.In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo +14 more
wiley +1 more source
Assisted Suicide and Euthanasia: Arguing for a Distinction [PDF]
, 2004 In this essay, I will try to analyze the problems of assisted suicide and euthanasia by using the Joel Feinberg’s analysis of the so-called ‘right to life’ and the Wesley Hohfeld’s legal terminology.
Del Bò, Corrado
core +1 more source
Nursing and euthanasia : a narrative review of the nursing ethics literature [PDF]
, 2020 Background: Medical Assistance in Dying, also known as euthanasia or assisted suicide, is expanding internationally. Canada is the first country to permit Nurse Practitioners to provide euthanasia.
Burgess, Michael +7 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang +15 more
wiley +1 more source
Swiss Medical WeeklyCONTEXT AND GOAL: This research addresses the issue of suicide and attempted suicide, which have a significant impact on global premature mortality and disability.
Annora Mack +3 more
doaj +1 more source