Results 121 to 130 of about 42,589 (258)

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

Surviving the Tsunami of Receiving a 'Goodbye' Note. [PDF]

J Psychiatr Ment Health Nurs
Haghiri-Vijeh R, Paul A.
europepmc   +1 more source

Oral GLP‐1RA TERN‐601 for Adults With Obesity/Overweight: Placebo‐Controlled, Multiple‐Ascending‐Dose, Phase 1 and 2 Studies

Obesity, EarlyView.
ABSTRACT Objective The safety, tolerability, pharmacokinetics, and efficacy of TERN‐601, a once‐daily, oral small‐molecule glucagon‐like peptide‐1 (GLP‐1) receptor agonist, were studied in Phase 1 and 2 clinical studies. Methods The Phase 1 (28‐day) and Phase 2 (12‐week), randomized, double‐blind, placebo‐controlled, multiple‐ascending‐dose studies ...
W. Timothy Garvey, Julio Rosenstock, Harold E. Bays, Douglas Denham, Anita Kohli, Melanie Haines, Christopher Jones, Ellen Kwan, Erin Castelloe, Tonya Marmon, Emil Kuriakose, Cara Nelson   +11 more
wiley   +1 more source

Characteristics of Adolescents and Young Adults Visiting an Emergency Department Due to Self-Harm or Suicide Attempts: Risk Factors for Severe Medical Outcome and Short-Term Revisits. [PDF]

J Korean Med Sci
Park K, Kim TH, Song KJ, Shin J, Jung JH, Lee HJ, Kim YH, Lee SGW.   +7 more
europepmc   +1 more source

Sources of Strength for School‐Based Suicide Prevention: Key Implementation Strategies Based on School Professional Perspectives

Psychology in the Schools, EarlyView.
ABSTRACT As concerns for rising rates of youth suicide and suicidal thoughts and behaviors continue to grow, there is a need to prioritize school‐based suicide prevention programs. Despite evidence documenting the effectiveness of school‐based prevention programs for reducing suicide‐related risk in adolescents, schools face numerous barriers to ...
Marisa E. Marraccini, Maya Gutman, Layne A. Wetherbee, Jessica R. Jacobs, Donald Christian Fisher, Dorothy L. Espelage, Sarah Haley McGlothin, Denise Yookong Williams, Paul Lanier   +8 more
wiley   +1 more source

Development of a Repeat Suicide Risk Management Protocol for Emergency Department Patients With Suicide Attempts: An Exploratory Sequential Mixed-Methods Study. [PDF]

Int J Ment Health Nurs
Tan R, Teng F, Wang JQ, Wang YD, Li LC, Hu DY.   +5 more
europepmc   +1 more source

Accidental plant poisonings in France: Lessons from a decade of national toxicovigilance

PLANTS, PEOPLE, PLANET, EarlyView.
Accidental plant poisonings reveal how modern societies are losing everyday botanical knowledge once central to food and health safety. By analyzing a decade of French toxicovigilance data, this study shows that most severe cases arise from plant misidentification or misguided self‐medication.
Gaël Le Roux, Adrien Maillot, Sylvie Michel, Jérôme Langrand, Sébastien Larréché, Christine Tournoud, David Boels, Magali Labadie, Nicolas Delcourt, Nathalie Paret, Luc de Haro, Sandra Sinno‐Tellier   +11 more
wiley   +1 more source

Impact of Tailored Interventions on Suicidal Ideation Recovery: Addressing Hopelessness Among Economically Vulnerable Populations During COVID-19 Period. [PDF]

J Korean Med Sci
Kim NY, Han DH, Hwang H, Lee HJ, Kim SM.
europepmc   +1 more source

Diagnostic Yield of EBUS Mediastinal Cryobiopsy Versus TBNA in Suspected Lymphoproliferative Disorders: A Prospective Multicentre Study

Respirology, EarlyView.
We assessed the diagnostic yield of EBUS‐guided transbronchial mediastinal cryobiopsy (EBUS‐TBMC) compared with EBUS‐transbronchial needle aspiration (EBUS‐TBNA) in patients with suspected mediastinal lymphoproliferative disorders (LPDs). EBUS‐TBMC was superior to EBUS‐TBNA and achieved a high diagnostic yield in patients with suspected mediastinal ...
Yaniv Dotan, Ayal Romem, Elad Guber, Michael Kassirer, Daphne Felus, Nimrod Urtreger, Ophir Freund, Hanna A. Dawood, Boaz Tiran, Doron Cohn‐Schwartz, Sarah Borsekofsky, Amir Bar‐Shai, Evgeni Gershman   +12 more
wiley   +1 more source

Childhood exposure to interpersonal and animal-directed violence: adversity profiles and adult suicidality. [PDF]

Front Psychiatry
McDonald SE, Tomlinson C, Freedenthal S, Bright CL, Malone A, Nicotera N, Kogan L, Van Buiten H, Ford J.   +8 more
europepmc   +1 more source