Results 21 to 30 of about 47,593 (259)

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Depression, Acquired Capability for Suicide, and Attempted Suicide

, 2019
Objective: The study sought to replicate, with a community sample and different measures of the critical variables, the finding of Chu et al. (Cognitive Therapy and Research, 2016, 40, 22) in a military sample that suicide attempts were more frequent for
Rimkeviciene, Jurgita, Ferriman, Matthew, Hawgood, Jacinta, Jurgita Rimkeviciene, John O'Gorman, Matthew Ferriman, Jacinta Hawgood, O'Gorman, John   +7 more
core   +1 more source

Psychiatric features of seriously life-threatening suicide attempters [PDF]

, 2003
Objective: Although attempted suicide is one of the strongest predictors of completed suicide, few Japanese studies have described psychiatric differences between those who attempt suicide by overdose (OD) and those who use more violent methods (MV ...
Satomi Murase, Murase, Satomi, 村瀬, 聡美, Ochiai, Shisei, Shuji Honjo, Tatsuro Ohta, Honjo, Shuji, Masashi Ueyama, Shisei Ochiai, Ohta, Tatsuro, Ueyama, Masashi   +10 more
core   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

The psychosocial toll of Dublin III on asylum seekers in the Netherlands

American Journal of Community Psychology, EarlyView.
Abstract The Dublin III Regulation determines which EU Member State is responsible for examining asylum claims, but its implementation carries significant consequences for those subjected to it. This study examines how Dublin III, as implemented in the Netherlands, affects asylum seekers' psychosocial wellbeing using Silove′s Adaptation and Development
Imen El Amouri
wiley   +1 more source

Using photovoice to understand community perceptions of firearm risks and protective factors among Asian Americans

American Journal of Community Psychology, EarlyView.
Abstract This study used photovoice methodology to explore Asian Americans' perspectives on the root causes and protective factors of firearm violence in their communities. Photovoice provided a participatory platform for community members to document lived experiences and identify priorities for change.
Tsu‐Yin Wu, Szu‐Hsien Chen, Xining Yang, Ken Resnicow, Hsing‐Fang Hsieh   +4 more
wiley   +1 more source

Victim, perpetrator, and offense characteristics in filicide and filicide-suicide [PDF]

, 2015
The purpose of this paper is to provide a critical review of most recent studies of parental and stepparental filicide. A detailed review of the literature revealed the importance of certain demographic, environmental, and psychosocial factors in the ...
Dhingra, Katie, Dhingra, K, Debowska, Agata, Boduszek, D, Debowska, A, Boduszek, Daniel   +5 more
core   +1 more source

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

ASSIP Attempted Suicide Short Intervention Program. A Manual for Clinicans

, 2015
Attempted Suicide is the main risk factor for suicide. The Attempted Suicide Short Intervention Program (ASSIP) described in this manual is an innovative brief therapy that has proven to be highly effective in reducing the risk of further attempts. ASSIP
Konrad Michel, Anja Gysin-Maillart, Gysin-Maillart, Anja, Michel, Konrad   +3 more
core   +1 more source

Border harm and affective injustice: The politics of anger at the Melilla border, Spain

American Journal of Community Psychology, EarlyView.
Abstract This article examines protests in a detention center in Melilla, Spain—a site where structural violence intersects with the everyday harms of confinement. Adopting a justice and dignity‐centered perspective, we analyze grassroots forms of resistance emerging at the border. The study focuses on the protests of Tunisian migrants and explores the
Corina Tulbure
wiley   +1 more source