Results 201 to 210 of about 1,176,128 (395)

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

Suicide by Swallowing a Spoon [PDF]

, 1899

openalex   +1 more source

The Interpersonal Theory of Suicide: A Systematic Review and Meta-Analysis of a Decade of Cross-National Research

Psychological bulletin, 2017
Carol Chu, Jennifer M Buchman-Schmitt, Ian H. Stanley, Melanie A. Hom, Raymond P. Tucker, C. Hagan, Megan L. Rogers, Matthew C. Podlogar, Bruno Chiurliza, Fallon B. Ringer, Matthew S Michaels, Connor H. G. Patros, T. Joiner   +12 more
semanticscholar   +1 more source

Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics

ChemMedChem, EarlyView.
Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch, Hernan A. Bazán, Nicolas G. Bazan, Bhattacharjee Surjyadipta, Julio Alvarez‐Builla, Beatriz de Pascual‐Teresa   +5 more
wiley   +1 more source

Do Scorpions Commit Suicide? [PDF]

, 1887

openalex   +1 more source

Labor Market Conditions, Political Events and Palestinian Suicide Bombings [PDF]

Objectives. This paper analyzes the relationship between Palestinian suicide bombings and economic and political conditions from 1993 to 2001. Labor market conditions could affect the number of terror attacks because when the economy worsens, the ...
Edward A. Sayre
core  

Effects of Ambient and Display Lighting Color on Risk‐Taking Behavior, Perceived Emotional States, and Visual Quality of Indoor Environment

Color Research &Application, EarlyView.
In a digital risk‐taking test, participants inflated a balloon to increase earned points at the risk of popping under different display and ambient lighting conditions. ABSTRACT Lighting from architectural fixtures and screens can have impacts beyond visual perception, such as occupants' cognitive functions and emotional states. Despite the ubiquity of
Naser Shehab, Dorukalp Durmus
wiley   +1 more source

Gun control and suicide: The impact of state firearm regulations, 1995–2004 [PDF]

Suicide is a major cause of preventable death. Restricting access to lethal means has been identified as an effective approach to suicide prevention, and firearms regulations are one way to reduce gun availability.
Antonio Rodríguez, Katherine Hempstead
core   +3 more sources

A suicide [PDF]

, 1872
Clarry
openalex   +1 more source

Exposure–Response Analysis for Aripiprazole Once‐Monthly in Patients Diagnosed With Bipolar I Disorder

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Aripiprazole once‐monthly (AOM) is approved for the maintenance monotherapy treatment of bipolar I disorder (BP‐I) in adults. A previously developed population pharmacokinetic model was validated by applying it to data from patients diagnosed with BP‐I.
Xiaofeng Wang, Luann Phillips, Matthew Harlin, Karimah S. Bell Lynum, Frank Larsen, Pedro Such, Jessica Madera‐McDonough, Murat Yildirim, Ric M. Procyshyn, Craig Chepke, Julie Passarell   +10 more
wiley   +1 more source