Results 141 to 150 of about 349,298 (311)
Report for Cooperation and Working Together of the Ireland North South urban rural epidemiological study of suicidal behaviour. [PDF]
, 2006 The prevention of suicide and suicide attempts remains a challenge for clinicians in Health Care provision. Suicide and attempted suicide (now usually termed “deliberate self-harm” or “self-harm” in the United Kingdom) are major problems in most ...
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Adverse Childhood Experiences in Autistic and Neurotypical Girls
Autism Research, EarlyView.ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun +4 more
wiley +1 more source
Substance Use and Suicidal Behaviors Among Young Adults [PDF]
The purpose of this paper is to examine the causal impact of alcohol and illicit drug use on suicidal behaviors among college students. Every year, more American youth die from suicide than from all leading natural causes of death combined. Substance use
Dhaval Dave +3 more
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Analysis of suicide behaviors in the Navy active duty and reserve component population [PDF]
, 2015 We analyze the role of service-specific and mental health risk factors in active duty and reserve component Navy enlisted and officer suicide attempts and deaths from 2002 to 2011.
Blankenship, Neeta Serena +1 more
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British Journal of Clinical Pharmacology, EarlyView.Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon +12 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Digital HealthObjective To construct applicable models suitable for predicting the risk of suicidal behavior among individuals with depression, particularly on the progression from no history of suicidal behavior to suicide attempts, as well as from suicidal ideation ...
Jian Zhang +9 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang +7 more
wiley +1 more source