Results 81 to 90 of about 349,298 (311)

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Prevalence of suicide attempts among college students in China: a meta-analysis. [PDF]

PLoS ONE, 2015
BACKGROUND:Suicide is the leading cause of death among 15-34 year olds in China, but no national data are available on the suicide and suicide attempts rates of college students, a sub-group of youth with 23 million.
Lin-Sheng Yang, Zhi-Hua Zhang, Liang Sun, Ye-Huan Sun, Dong-Qing Ye   +4 more
doaj   +1 more source

Epidemiology of suicidal ideation, suicide attempts, and direct self-injurious behavior in adolescents with a migration background : a representative study [PDF]

, 2019
Background: Data on the prevalence of suicidal ideation, suicide attempts, and direct self-injurious behavior in adolescents with a migration background are scarce. There are hints that this population is at risk.
Baier, Dirk, Bergmann, Marie Christine, Donath, Carolin, Hillemacher, Thomas, Kliem, Sören   +4 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

An approach for data mining of electronic health record data for suicide risk management: Database analysis for clinical decision support [PDF]

, 2019
Background: In an electronic health context, combining traditional structured clinical assessment methods and routine electronic health-based data capture may be a reliable method to build a dynamic clinical decision-support system (CDSS) for suicide ...
Baca-García, Enrique, Berrouiguet, Sofian, Billot, Romain, Courtet, Philippe, Jaussent, Isabelle, Larsen, Mark Erik, Lenca, Philippe, Lopez-Castroman, Jorge, Walter, Michel   +8 more
core   +5 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Broad and narrow personality traits as markers of one-time and repeated suicide attempts: A population-based study [PDF]

, 2008
Background Studying personality traits with the potential to differentiate between individuals engaging in suicide attempts of different degrees of severity could help us to understand the processes underlying the link of personality and nonfatal ...
Jelena Brezo, Joel Paris, Martine Hébert, Frank Vitaro, Richard Tremblay, Gustavo Turecki, J Brezo, G Youssef, DM Fergusson, G Turecki, P Baud, D Stein, RF Krueger, RR McCrae, CR Cloninger, KL Jang, JJ Eysenck, SV Paunonen, R Shiner, RW Maris, MS Gould, MD Rudd, EM Forman, J Brezo, WJ Livesley, J Brezo, DM Fergusson, A Roy, A Roy, S Benjaminsen, DS Janowsky, RE Tremblay, S Cote, MA Straus, MA Straus, F D, VJ Felitti, J Horney, JJ Breton, H Steiger, E Barratt, H Heila, AF deMan, AT Beck, RW Beck, RJ Turner, DW Hosmer, I Sakinofsky, AG Wang, L Kotila, HC van, A Hawton, PTJ Costa, HJ Eysenck, Y Sarfati, CL Bagge, R Pukrop, M Brune, A Abdel-Khalek, A Ucok, L Scahill, J LeGris, RF Baumeister, NJ Kaslow, J Neeleman, EG Stalenheim, D Lester, B Pendse, MD Rudd, DB Goldston, L Seidlitz, A Dumais, RL Walker, AT Davis, M Mean, PT Costa Jr., A Roy, N Adler, T Bogg   +78 more
core   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Recommended care for young people (15-19 years) after suicide attempts in certain European countries [PDF]

, 2000
Data on recommended care for young people aged 15±19 years after attempted suicide from nine European research centres dur- ing the period 1989±1992 were ana- lysed in terms of gender, history of previous suicide attempt and meth- ods used.
Bille-Brahe, U, Bjerke, T, Hawton, K, Hultén, A, Jiang, GX, Kerkhkof, A, Michel, K, Querejeta, I, Salander-Renberg, E, Schmidtke, A, Wasserman, D   +10 more
core   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source